Popular Searches
Diphenyleneiodonium chlorideEpacadostatGilteritinibDinaciclibRo-3306
TargetMol | Star Product
Wikimole
TargetMol | New Product
New Product
TargetMol | Compound Library
Compound Library
Contact UsQuotation
Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

TrxR-IN-5

🥰Excellent
Catalog No. T61647

TrxR-IN-5 (compound 4f) is an effective inhibitor of thioredoxin reductase (TrxR) with an IC₅₀ of 0.16 μM. TrxR-IN-5 increases reactive oxygen species (ROS) levels, reverses TGFβ1-induced epithelial-mesenchymal transition, and exhibits anti-proliferative and anti-metastatic effects against human breast cancer cells.

TrxR-IN-5

TrxR-IN-5

🥰Excellent
Catalog No. T61647
TrxR-IN-5 (compound 4f) is an effective inhibitor of thioredoxin reductase (TrxR) with an IC₅₀ of 0.16 μM. TrxR-IN-5 increases reactive oxygen species (ROS) levels, reverses TGFβ1-induced epithelial-mesenchymal transition, and exhibits anti-proliferative and anti-metastatic effects against human breast cancer cells.
Pack SizePriceAvailabilityQuantity
1 mg$49In Stock
5 mg$199In Stock
Add to Cart
Add to Quotation
Bulk & Custom
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
View More

Batch Information

Select Batch
Contact us for more batch information

Resource Download

COA

Product Introduction

Bioactivity
Description
TrxR-IN-5 (compound 4f) is an effective inhibitor of thioredoxin reductase (TrxR) with an IC₅₀ of 0.16 μM. TrxR-IN-5 increases reactive oxygen species (ROS) levels, reverses TGFβ1-induced epithelial-mesenchymal transition, and exhibits anti-proliferative and anti-metastatic effects against human breast cancer cells.
Targets&IC50
TrxR:0.16 ± 0.02 μM
In vivo
In the MDA-MB-231 parazacco spilurus subsp. spilurus xenograft model of BALB/c nude mice, TrxR-IN-5 (compound 4f) (0-25 mg/kg, intraperitoneal injection, once) significantly inhibited the growth of breast cancer solid tumors. [1]
Chemical Properties
Molecular Weight382.46
FormulaC26H22O3
SmilesO=C1C=CCC/C1=C/C2=CC=C(OC3=CC=C(/C=C4CCC=CC\4=O)C=C3)C=C2
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (104.59 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6147 mL13.0733 mL26.1465 mL130.7326 mL
5 mM0.5229 mL2.6147 mL5.2293 mL26.1465 mL
10 mM0.2615 mL1.3073 mL2.6147 mL13.0733 mL
20 mM0.1307 mL0.6537 mL1.3073 mL6.5366 mL
50 mM0.0523 mL0.2615 mL0.5229 mL2.6147 mL
100 mM0.0261 mL0.1307 mL0.2615 mL1.3073 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: buy TrxR-IN-5 | purchase TrxR-IN-5 | TrxR-IN-5 cost | order TrxR-IN-5 | TrxR-IN-5 chemical structure | TrxR-IN-5 in vivo | TrxR-IN-5 formula | TrxR-IN-5 molecular weight
TargetMol | Logo

Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.