(Arg)9 acetate

Name: (Arg)9 acetate
Brand: TargetMol
SKU: T77998
Rating: 4.5 (1 reviews)

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Catalog No. T77998

Alias Peptide R9 acetate, Nona-L-arginine acetate

Nona-L-arginine (Arg)9 acetate, a cell-penetrating peptide (CPP) consisting of 9 arginine residues, displays neuroprotective properties, with an IC50 of 0.78 μM in the glutamic acid model [1] [2].

(Arg)9 acetate

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Catalog No. T77998Alias Peptide R9 acetate, Nona-L-arginine acetate

Nona-L-arginine (Arg)9 acetate, a cell-penetrating peptide (CPP) consisting of 9 arginine residues, displays neuroprotective properties, with an IC50 of 0.78 μM in the glutamic acid model [1] [2].

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Product Introduction

Bioactivity

Description	Nona-L-arginine (Arg)9 acetate, a cell-penetrating peptide (CPP) consisting of 9 arginine residues, displays neuroprotective properties, with an IC50 of 0.78 μM in the glutamic acid model [1] [2].
In vitro	(Arg)9 acetate, at concentrations of 5-10 μM, demonstrates substantial dose-dependent neuroprotection against glutamic acid exposure, with an IC50 value of 0.78 μM. Its neuroprotective efficacy is reduced in the kainic acid model, exhibiting an IC50 of 0.81 μM. Moreover, it provides neuroprotection in in vitro ischemic conditions, with an IC50 of 6 μM [1].
In vivo	The compound '(Arg)9' (Nona-L-arginine; administered intravenously at 1 μM/kg in a volume of 600 μL; once for 30 minutes) exhibits neuroprotective properties and decreases infarct size in male Sprague-Dawley rats using a permanent middle cerebral artery stroke model [2].
Synonyms	Peptide R9 acetate, Nona-L-arginine acetate

Chemical Properties

Molecular Weight	1483.74
Formula	C₅₆H₁₁₄N₃₆O₁₂
Sequence	Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg
Sequence Short	RRRRRRRRR

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc