Flupyradifurone (flupyradifurone) is a systemic insecticide and nicotinic acetylcholine receptor (nAChR) agonist that acts by interfering with the nervous system of insects.

Flupyradifurone acts as an agonist of nicotinic acetylcholine receptors (nAChRs) in insect nervous systems during in vitro electrophysiological studies. Flupyradifurone causes neuronal depolarization, disrupting nerve signal transmission and resulting in insect death[1].

In vivo studies in honey bees (Apis mellifera) show that oral administration of Flupyradifurone (1.2-3.9 µg/bee) causes transient but reversible neurobehavioral symptoms (e.g., tremors and disorientation) without mortality or long-term effects. Flupyradifurone also demonstrates high insecticidal activity against agricultural pests like whiteflies, aphids, and flea beetles, with strong efficacy in field trials[1].