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Zaloglanstat

Name: Zaloglanstat
Brand: TargetMol
SKU: T39000
Price: 165 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39000Cas No. 1513852-12-4

Alias ISC27864

Zaloglanstat (ISC-27864) is a selective, orally active mPGES-1 inhibitor with an IC50 of 5 nM against human mPGES-1, demonstrating analgesic effects in osteoarthritis and inflammatory arthritis.

Zaloglanstat

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Purity: 99.97%

Catalog No. T39000Alias ISC27864Cas No. 1513852-12-4

Zaloglanstat (ISC-27864) is a selective, orally active mPGES-1 inhibitor with an IC50 of 5 nM against human mPGES-1, demonstrating analgesic effects in osteoarthritis and inflammatory arthritis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$165	-	In Stock
5 mg	$413	-	In Stock
10 mg	$689	-	In Stock
25 mg	$1,450	-	In Stock
50 mg	$1,960	-	In Stock
100 mg	$2,630	-	In Stock
1 mL x 10 mM (in DMSO)	$455	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.97%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Zaloglanstat (ISC-27864) is a selective, orally active mPGES-1 inhibitor with an IC50 of 5 nM against human mPGES-1, demonstrating analgesic effects in osteoarthritis and inflammatory arthritis.
In vitro	Zaloglanstat exhibits selective inhibitory effects on both recombinant mPGES-1 activity and IL-1β in A549 cells, with IC50 values of 5 nM for both, while showing no significant inhibition on COX-1 and COX-2 (IC₅₀ >10 μM) [1]. In IL-1β-induced A549 cell and Homo sapiens synovial fibroblast models, Zaloglanstat can dose-dependently inhibit PGE₂ release, with an IC₅₀ value below 10 nM [1].
Synonyms	ISC27864

Chemical Properties

Molecular Weight	452.86
Formula	C₂₁H₂₀ClF₃N₄O₂
Cas No.	1513852-12-4
Smiles	CC(C)(C)C(=O)NCc1ccc(Cl)c(c1)-c1nn(-c2ccc(cc2)C(F)(F)F)c(=O)[nH]1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (441.64 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (7.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2082 mL	11.0409 mL	22.0819 mL	110.4094 mL
5 mM	0.4416 mL	2.2082 mL	4.4164 mL	22.0819 mL
10 mM	0.2208 mL	1.1041 mL	2.2082 mL	11.0409 mL
20 mM	0.1104 mL	0.5520 mL	1.1041 mL	5.5205 mL
50 mM	0.0442 mL	0.2208 mL	0.4416 mL	2.2082 mL
100 mM	0.0221 mL	0.1104 mL	0.2208 mL	1.1041 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc