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β-Bisabolene

Name: β-Bisabolene
Brand: TargetMol
SKU: T40578
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40578Cas No. 495-61-4

β-Bisabolene is a sesquiterpene natural product exhibiting cytotoxicity towards breast cancer cell lines, inducing apoptosis in MCF-10A, MDA-MB-231, and BT474 cells.

β-Bisabolene

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Catalog No. T40578Cas No. 495-61-4

β-Bisabolene is a sesquiterpene natural product exhibiting cytotoxicity towards breast cancer cell lines, inducing apoptosis in MCF-10A, MDA-MB-231, and BT474 cells.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$31	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Liquid

Color:Transparent

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COA HNMR

Product Introduction

Bioactivity

Description	β-Bisabolene is a sesquiterpene natural product exhibiting cytotoxicity towards breast cancer cell lines, inducing apoptosis in MCF-10A, MDA-MB-231, and BT474 cells.
In vitro	β-Bisabolene exhibits selective cytotoxicity: for murine cells, the half-maximal inhibitory concentration (IC₅₀) is >200 μg/ml for normal cells Eph4, 65.49 μg/ml for breast cancer cells MG1361, and 48.99 μg/ml for breast cancer cells 4T1; for Homo sapiens breast cancer cells, the IC₅₀ is 114.3 μg/ml for normal mammary epithelial cells MCF-10A, 66.91 μg/ml for breast cancer cells MCF-7, 98.39 μg/ml for breast cancer cells MDA-MB-231, 70.62 μg/ml for breast cancer cells SKBR3, and 74.3 μg/ml for breast cancer cells BT474. [1]
In vivo	In vivo experiments demonstrated that β-Bisabolene effectively inhibited the growth of transplanted 4T1 mammary tumors, reducing tumor volume by 37.5% at the experimental endpoint. [1]

Chemical Properties

Molecular Weight	204.35
Formula	C₁₅H₂₄
Cas No.	495-61-4
Smiles	C(CCC=C(C)C)(=C)[C@H]1CCC(C)=CC1
Relative Density.	0.8673 g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (391.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (16.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8936 mL	24.4678 mL	48.9356 mL	244.6782 mL
5 mM	0.9787 mL	4.8936 mL	9.7871 mL	48.9356 mL
10 mM	0.4894 mL	2.4468 mL	4.8936 mL	24.4678 mL
20 mM	0.2447 mL	1.2234 mL	2.4468 mL	12.2339 mL
50 mM	0.0979 mL	0.4894 mL	0.9787 mL	4.8936 mL
100 mM	0.0489 mL	0.2447 mL	0.4894 mL	2.4468 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc