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LQVTDSGLYRCVIYHPP
🥰Excellent
Catalog No. T78025Cas No. 887255-16-5
Alias LP17
LQVTDSGLYRCVIYHPP (LP17) is a peptide and TREM-1 (Triggering Receptor Expressed on Myeloid cells 1) inhibitor derived from a highly conserved sequence between the extracellular structural domains of mouse and human TREM-1 and TLT-1.LP17 inhibits TREM-1 activation through a decoy receptor LP17 inhibits TREM-1 activation by actin through a decoy receptor mechanism, which has the advantage of penetrating the brain barrier and attenuating neuronal damage and inflammatory responses.
LQVTDSGLYRCVIYHPP
🥰Excellent
Catalog No. T78025Alias LP17Cas No. 887255-16-5
LQVTDSGLYRCVIYHPP (LP17) is a peptide and TREM-1 (Triggering Receptor Expressed on Myeloid cells 1) inhibitor derived from a highly conserved sequence between the extracellular structural domains of mouse and human TREM-1 and TLT-1.LP17 inhibits TREM-1 activation through a decoy receptor LP17 inhibits TREM-1 activation by actin through a decoy receptor mechanism, which has the advantage of penetrating the brain barrier and attenuating neuronal damage and inflammatory responses.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $60 | In Stock | |
| 5 mg | $147 | In Stock | |
| 10 mg | $263 | In Stock | |
| 25 mg | $446 | In Stock | |
| 50 mg | $645 | In Stock | |
| 100 mg | $886 | In Stock | |
| 500 mg | $1,790 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | LQVTDSGLYRCVIYHPP (LP17) is a peptide and TREM-1 (Triggering Receptor Expressed on Myeloid cells 1) inhibitor derived from a highly conserved sequence between the extracellular structural domains of mouse and human TREM-1 and TLT-1.LP17 inhibits TREM-1 activation through a decoy receptor LP17 inhibits TREM-1 activation by actin through a decoy receptor mechanism, which has the advantage of penetrating the brain barrier and attenuating neuronal damage and inflammatory responses. |
| In vitro | In primary rat microglial cells, LQVTDSGLYRCVIYHPP (100 nM, 1-hour pretreatment) significantly inhibited hemoglobin-induced inflammation by reducing the expression of TREM-1, TNF-α, IL-1β, IL-6, and iNOS. It also decreased nitric oxide production and suppressed NF-κB p65 nuclear translocation, indicating strong anti-inflammatory effects[1]. |
| In vivo | In a rat model of subarachnoid hemorrhage (SAH), intracerebroventricular injection of LQVTDSGLYRCVIYHPP (0.5 μg) significantly suppressed TREM-1 and proinflammatory cytokine expression, reduced neuronal apoptosis, and improved neurological scores, demonstrating potent anti-inflammatory and neuroprotective effects[1]. |
| Alias | LP17 |
| Molecular Weight | 1961.24 |
| Formula | C89H137N23O25S |
| Cas No. | 887255-16-5 |
| Smiles | C(=O)([C@H]1N(C([C@H](CC2=CN=CN2)NC([C@H](CC3=CC=C(O)C=C3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CC=C(O)C=C4)NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)N)=O)CCC(N)=O)=O)C(C)C)=O)[C@@H](C)O)=O)CC(O)=O)=O)CO)=O)=O)CC(C)C)=O)=O)CCCNC(=N)N)=O)CS)=O)[C@H](C)C)=O)[C@H](CC)C)=O)=O)=O)CCC1)N5[C@H](C(O)=O)CCC5 |
Storage & Solubility Information
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | H2O: 10 mg/mL (5.1 mM), when pH is adjusted to 3 with CH3COOH. Sonication and heating are recommended. DMSO: 15 mg/mL (7.65 mM), when pH is adjusted to 7 with CH3COOH. Sonication and heating are recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
H2O/DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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