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LQVTDSGLYRCVIYHPP (Synonyms: LP17)

Name: LQVTDSGLYRCVIYHPP
Brand: TargetMol
SKU: T78025
Price: 60 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T78025 Copy Product Info

Purity: 99.59%

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LQVTDSGLYRCVIYHPP (LP17) is a peptide and TREM-1 (Triggering Receptor Expressed on Myeloid cells 1) inhibitor derived from a highly conserved sequence between the extracellular structural domains of mouse and human TREM-1 and TLT-1.LP17 inhibits TREM-1 activation through a decoy receptor LP17 inhibits TREM-1 activation by actin through a decoy receptor mechanism, which has the advantage of penetrating the brain barrier and attenuating neuronal damage and inflammatory responses.

LQVTDSGLYRCVIYHPP

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Catalog No. T78025

Synonyms LP17

Cas No. 887255-16-5

Pack Size	Price	USA Stock	Global Stock
1 mg	$60	-	In Stock
5 mg	$147	-	In Stock
10 mg	$263	-	In Stock
25 mg	$446	-	In Stock
50 mg	$645	-	In Stock
100 mg	$886	-	In Stock
500 mg	$1,790	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.59%

Appearance:Solid

Color:White

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COA HPLC MS

Product Introduction

Bioactivity

Description	LQVTDSGLYRCVIYHPP (LP17) is a peptide and TREM-1 (Triggering Receptor Expressed on Myeloid cells 1) inhibitor derived from a highly conserved sequence between the extracellular structural domains of mouse and human TREM-1 and TLT-1.LP17 inhibits TREM-1 activation through a decoy receptor LP17 inhibits TREM-1 activation by actin through a decoy receptor mechanism, which has the advantage of penetrating the brain barrier and attenuating neuronal damage and inflammatory responses.
In vitro	In primary rat microglial cells, LQVTDSGLYRCVIYHPP (100 nM, 1-hour pretreatment) significantly inhibited hemoglobin-induced inflammation by reducing the expression of TREM-1, TNF-α, IL-1β, IL-6, and iNOS. It also decreased nitric oxide production and suppressed NF-κB p65 nuclear translocation, indicating strong anti-inflammatory effects[1].
In vivo	In a rat model of subarachnoid hemorrhage (SAH), intracerebroventricular injection of LQVTDSGLYRCVIYHPP (0.5 μg) significantly suppressed TREM-1 and proinflammatory cytokine expression, reduced neuronal apoptosis, and improved neurological scores, demonstrating potent anti-inflammatory and neuroprotective effects[1].
Synonyms	LP17

Chemical Properties

Molecular Weight	1961.24
Formula	C₈₉H₁₃₇N₂₃O₂₅S
Cas No.	887255-16-5
Smiles	C(=O)([C@H]1N(C([C@H](CC2=CN=CN2)NC([C@H](CC3=CC=C(O)C=C3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CC=C(O)C=C4)NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)N)=O)CCC(N)=O)=O)C(C)C)=O)[C@@H](C)O)=O)CC(O)=O)=O)CO)=O)=O)CC(C)C)=O)=O)CCCNC(=N)N)=O)CS)=O)[C@H](C)C)=O)[C@H](CC)C)=O)=O)=O)CCC1)N5[C@H](C(O)=O)CCC5
Sequence	Leu-Gln-Val-Thr-Asp-Ser-Gly-Leu-Tyr-Arg-Cys-Val-Ile-Tyr-His-Pro-Pro
Sequence Short	LQVTDSGLYRCVIYHPP

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 10 mg/mL (5.1 mM), when pH is adjusted to 3 with CH3COOH. Sonication and heating are recommended.

DMSO: 15 mg/mL (7.65 mM), when pH is adjusted to 7 with CH3COOH. Sonication and heating are recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.5099 mL	2.5494 mL	5.0988 mL	25.4941 mL
5 mM	0.1020 mL	0.5099 mL	1.0198 mL	5.0988 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc