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LQVTDSGLYRCVIYHPP

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Catalog No. T78025Cas No. 887255-16-5
Alias LP17

LQVTDSGLYRCVIYHPP (LP17) is a peptide and TREM-1 (Triggering Receptor Expressed on Myeloid cells 1) inhibitor derived from a highly conserved sequence between the extracellular structural domains of mouse and human TREM-1 and TLT-1.LP17 inhibits TREM-1 activation through a decoy receptor LP17 inhibits TREM-1 activation by actin through a decoy receptor mechanism, which has the advantage of penetrating the brain barrier and attenuating neuronal damage and inflammatory responses.

LQVTDSGLYRCVIYHPP
Other Forms of LQVTDSGLYRCVIYHPP:
Lqvtdsglyrcviyhpp TFAT78026
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LQVTDSGLYRCVIYHPP

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Purity: 99.59%
Catalog No. T78025Alias LP17Cas No. 887255-16-5
LQVTDSGLYRCVIYHPP (LP17) is a peptide and TREM-1 (Triggering Receptor Expressed on Myeloid cells 1) inhibitor derived from a highly conserved sequence between the extracellular structural domains of mouse and human TREM-1 and TLT-1.LP17 inhibits TREM-1 activation through a decoy receptor LP17 inhibits TREM-1 activation by actin through a decoy receptor mechanism, which has the advantage of penetrating the brain barrier and attenuating neuronal damage and inflammatory responses.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$60-In Stock
5 mg$147-In Stock
10 mg$263-In Stock
25 mg$446-In Stock
50 mg$645-In Stock
100 mg$886-In Stock
500 mg$1,790-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.59%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
LQVTDSGLYRCVIYHPP (LP17) is a peptide and TREM-1 (Triggering Receptor Expressed on Myeloid cells 1) inhibitor derived from a highly conserved sequence between the extracellular structural domains of mouse and human TREM-1 and TLT-1.LP17 inhibits TREM-1 activation through a decoy receptor LP17 inhibits TREM-1 activation by actin through a decoy receptor mechanism, which has the advantage of penetrating the brain barrier and attenuating neuronal damage and inflammatory responses.
In vitro
In primary rat microglial cells, LQVTDSGLYRCVIYHPP (100 nM, 1-hour pretreatment) significantly inhibited hemoglobin-induced inflammation by reducing the expression of TREM-1, TNF-α, IL-1β, IL-6, and iNOS. It also decreased nitric oxide production and suppressed NF-κB p65 nuclear translocation, indicating strong anti-inflammatory effects[1].
In vivo
In a rat model of subarachnoid hemorrhage (SAH), intracerebroventricular injection of LQVTDSGLYRCVIYHPP (0.5 μg) significantly suppressed TREM-1 and proinflammatory cytokine expression, reduced neuronal apoptosis, and improved neurological scores, demonstrating potent anti-inflammatory and neuroprotective effects[1].
SynonymsLP17
Chemical Properties
Molecular Weight1961.24
FormulaC89H137N23O25S
Cas No.887255-16-5
SmilesC(=O)([C@H]1N(C([C@H](CC2=CN=CN2)NC([C@H](CC3=CC=C(O)C=C3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CC=C(O)C=C4)NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)N)=O)CCC(N)=O)=O)C(C)C)=O)[C@@H](C)O)=O)CC(O)=O)=O)CO)=O)=O)CC(C)C)=O)=O)CCCNC(=N)N)=O)CS)=O)[C@H](C)C)=O)[C@H](CC)C)=O)=O)=O)CCC1)N5[C@H](C(O)=O)CCC5
SequenceLeu-Gln-Val-Thr-Asp-Ser-Gly-Leu-Tyr-Arg-Cys-Val-Ile-Tyr-His-Pro-Pro
Sequence ShortLQVTDSGLYRCVIYHPP
Storage & Solubility Information
Storagekeep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 10 mg/mL (5.1 mM), when pH is adjusted to 3 with CH3COOH. Sonication and heating are recommended.
DMSO: 15 mg/mL (7.65 mM), when pH is adjusted to 7 with CH3COOH. Sonication and heating are recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM0.5099 mL2.5494 mL5.0988 mL25.4941 mL
5 mM0.1020 mL0.5099 mL1.0198 mL5.0988 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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