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CP-868388 free base

Name: CP-868388 free base
Brand: TargetMol
SKU: T31083
Rating: 4.5 (1 reviews)

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Catalog No. T31083Cas No. 702681-67-2

Alias UNII-999KY5ZIGB, CP-868388, CP868388, CP 868388, (-)-CP-868388

CP-868388 free base (CP-868388) is an orally active, potent and selective PPARα agonist with hypolipidemic and anti-inflammatory activity for the study of dyslipidemia.

CP-868388 free base

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Purity: 99.84%

Catalog No. T31083Alias UNII-999KY5ZIGB, CP-868388, CP868388, CP 868388, (-)-CP-868388Cas No. 702681-67-2

CP-868388 free base (CP-868388) is an orally active, potent and selective PPARα agonist with hypolipidemic and anti-inflammatory activity for the study of dyslipidemia.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$52	5 days	5 days
5 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.84%

Appearance:Solid

Color:White

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COA HNMR ORP LCMS

Product Introduction

Bioactivity

Description	CP-868388 free base (CP-868388) is an orally active, potent and selective PPARα agonist with hypolipidemic and anti-inflammatory activity for the study of dyslipidemia.
Targets&IC50	PPARα (human):10.8 nM (Ki), PPARγ (human):3.47 μM (Ki), HepG2 cells:18 nM (EC50), SRC-1:4.7 nM (EC50)
In vitro	The compound CP-868388, at concentrations ranging from 0-1 mM, exhibits strong and dose-dependent recruitment of SRC-1, with an EC50 of 4.7 nM, as well as the PGC-1α peptide[1]. Additionally, CP-868388 demonstrates potent and selective transcriptional activation of PPARα, showing an EC50 of 18 nM in HepG2 cells[1].
In vivo	In male B6/CBF1J mice, treatment with CP-868388 (oral gavage; once daily; for 2 days) at doses ranging from 0-3 mg/kg results in a robust and highly significant decrease in circulating plasma triglycerides. The dose-dependent effect is observed, with the highest efficacy achieved at the 3.0 mg/kg dose, leading to a reduction of approximately 50% in triglyceride levels[1].
Synonyms	UNII-999KY5ZIGB, CP-868388, CP868388, CP 868388, (-)-CP-868388

Chemical Properties

Molecular Weight	439.54
Formula	C₂₆H₃₃NO₅
Cas No.	702681-67-2
Smiles	CC(C)c1ccc(COC(=O)N2CCC[C@H](C2)c2cccc(OC(C)(C)C(O)=O)c2)cc1
Relative Density.	1.161 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (227.51 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2751 mL	11.3755 mL	22.7511 mL	113.7553 mL
5 mM	0.4550 mL	2.2751 mL	4.5502 mL	22.7511 mL
10 mM	0.2275 mL	1.1376 mL	2.2751 mL	11.3755 mL
20 mM	0.1138 mL	0.5688 mL	1.1376 mL	5.6878 mL
50 mM	0.0455 mL	0.2275 mL	0.4550 mL	2.2751 mL
100 mM	0.0228 mL	0.1138 mL	0.2275 mL	1.1376 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc