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GABAA receptor agent 8
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Catalog No. T60826Cas No. 2376841-54-0
GABAA receptor agent 8 (compound 5e) is a potent positive modulator of the GABAA receptor, exhibiting anticonvulsant activity in both in vitro and in vivo studies, with low neurotoxicity, indicating its potential in epilepsy research [1].
GABAA receptor agent 8
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Catalog No. T60826Cas No. 2376841-54-0
GABAA receptor agent 8 (compound 5e) is a potent positive modulator of the GABAA receptor, exhibiting anticonvulsant activity in both in vitro and in vivo studies, with low neurotoxicity, indicating its potential in epilepsy research [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | GABAA receptor agent 8 (compound 5e) is a potent positive modulator of the GABAA receptor, exhibiting anticonvulsant activity in both in vitro and in vivo studies, with low neurotoxicity, indicating its potential in epilepsy research [1]. |
| In vitro | GABAA receptor agent 8 (compound 5e) demonstrates anticonvulsant activity, evidenced by an IC50 of 0.334 μM in the 4-AP induced hyper-excitability model [1]. Additionally, this compound enhances GABA-induced activation of the GABAA1 receptor in a dose-dependent manner over a range of 0.01-100 μM and a duration of 0-140 seconds, with an EC50 of 12.02 μM. |
| In vivo | GABAA receptor agent 8 (compound 5e) demonstrates anticonvulsant efficacy in mice, exhibiting an effective dose (ED50) of 40.95 mg/kg and a toxic dose (TD50) of 372.39 mg/kg [1]. This agent specifically mitigates seizures induced by pentylenetetrazol (PTZ) without affecting those caused by maximal electroshock (MES) in mice [1]. |
| Molecular Weight | 316.36 |
| Formula | C19H16N4O |
| Cas No. | 2376841-54-0 |
| Smiles | O=C1N2C(NC(=N2)C3=CC=C(C)C=C3)=NC(CC4=CC=CC=C4)=C1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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