Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GABAA receptor agent 8 (compoud 5e) has the potential in epilepsy research. GABAA receptor agent 8 is a potent positive modulator of GABAA receptor with anticonvulsant activity both in vitro and in vivo as well as low neurotoxicity [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | GABAA receptor agent 8 (compoud 5e) has the potential in epilepsy research. GABAA receptor agent 8 is a potent positive modulator of GABAA receptor with anticonvulsant activity both in vitro and in vivo as well as low neurotoxicity [1]. |
In vitro | GABAA receptor agent 8 (compound 5e) demonstrates anticonvulsant activity, evidenced by an IC50 of 0.334 μM in the 4-AP induced hyper-excitability model [1]. Additionally, this compound enhances GABA-induced activation of the GABAA1 receptor in a dose-dependent manner over a range of 0.01-100 μM and a duration of 0-140 seconds, with an EC50 of 12.02 μM. |
In vivo | GABAA receptor agent 8 (compound 5e) demonstrates anticonvulsant efficacy in mice, exhibiting an effective dose (ED50) of 40.95 mg/kg and a toxic dose (TD50) of 372.39 mg/kg [1]. This agent specifically mitigates seizures induced by pentylenetetrazol (PTZ) without affecting those caused by maximal electroshock (MES) in mice [1]. |
Molecular Weight | 316.36 |
Formula | C19H16N4O |
CAS No. | 2376841-54-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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GABAA receptor agent 8 2376841-54-0 inhibitor inhibit