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CFTR corrector 9

Name: CFTR corrector 9
Brand: TargetMol
SKU: T60653
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60653Cas No. 909861-78-5

CFTR Corrector 9, a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, is employed in the research of cystic fibrosis (CF) and related CFTR-associated disorders [1].

CFTR corrector 9

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Purity: 99.75%

Catalog No. T60653Cas No. 909861-78-5

CFTR Corrector 9, a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, is employed in the research of cystic fibrosis (CF) and related CFTR-associated disorders [1].

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	-	In Stock
5 mg	$58	-	In Stock
10 mg	$93	-	In Stock
25 mg	$188	-	In Stock
50 mg	$281	-	In Stock
100 mg	$403	-	In Stock
200 mg	$566	-	In Stock
1 mL x 10 mM (in DMSO)	$56	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.75%

Appearance:Solid

Color:Red

Resource Download

COA LCMS HNMR

Product Introduction

CFTR corrector 9 AI Summary

CFTR corrector 9 exhibits a broad spectrum of bioactivities according to various assays. It shows potency in modulating miRNAs, activating the Rab9 and NPC1 promoters, enhancing SMN2 splice variant expression, and inhibiting ROR gamma transcriptional activity, as well as reactivating p53. Additionally, it inhibits chronic active B-Cell receptor signaling, induces genotoxicity in HEK293T cells, and inhibits histone lysine methyltransferase G9a, ELG1-dependent DNA repair, malarial parasite plastid, and the binding/entry of Lassa Virus into cells. Besides these, it also inhibits firefly luciferase and functions as an inverse agonist for the GLP-1 receptor and an agonist for gsp. The compound's activities demonstrate varying levels of effectiveness, with potencies ranging from 501.2 nM to 79432.8 nM across different bioassays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

CFTR Corrector 9, a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, is employed in the research of cystic fibrosis (CF) and related CFTR-associated disorders [1].

Chemical Properties

Molecular Weight	298.29
Formula	C₁₆H₁₄N₂O₄
Cas No.	909861-78-5
Smiles	COc1cccc(c1)-c1cc(no1)C(=O)NCc1ccco1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 112.5 mg/mL (377.15 mM), Sonication and heating to 80℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3524 mL	16.7622 mL	33.5244 mL	167.6221 mL
5 mM	0.6705 mL	3.3524 mL	6.7049 mL	33.5244 mL
10 mM	0.3352 mL	1.6762 mL	3.3524 mL	16.7622 mL
20 mM	0.1676 mL	0.8381 mL	1.6762 mL	8.3811 mL
50 mM	0.0670 mL	0.3352 mL	0.6705 mL	3.3524 mL
100 mM	0.0335 mL	0.1676 mL	0.3352 mL	1.6762 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc