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Latanoprost ethyl amide
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Catalog No. T37627Cas No. 607351-44-0
Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters exhibit ocular hypotensive activity, and prostaglandin N-ethyl amides have recently been introduced as alternative ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to free acids in vivo, studies in our laboratories show that bovine and human corneal tissue can convert the N-ethyl amides of various prostaglandins to free acids at a rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt is expected to exhibit the typical intraocular effects of latanoprost free acid, but with much slower hydrolysis pharmacokinetics characteristic of prostaglandin N-amides.
Latanoprost ethyl amide
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Catalog No. T37627Cas No. 607351-44-0
Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters exhibit ocular hypotensive activity, and prostaglandin N-ethyl amides have recently been introduced as alternative ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to free acids in vivo, studies in our laboratories show that bovine and human corneal tissue can convert the N-ethyl amides of various prostaglandins to free acids at a rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt is expected to exhibit the typical intraocular effects of latanoprost free acid, but with much slower hydrolysis pharmacokinetics characteristic of prostaglandin N-amides.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $265 | 35 days | 35 days | |
| 5 mg | $1,130 | 35 days | 35 days | |
| 10 mg | $1,980 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Chemical Properties
Storage & Solubility Information
| Description | Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters exhibit ocular hypotensive activity, and prostaglandin N-ethyl amides have recently been introduced as alternative ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to free acids in vivo, studies in our laboratories show that bovine and human corneal tissue can convert the N-ethyl amides of various prostaglandins to free acids at a rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt is expected to exhibit the typical intraocular effects of latanoprost free acid, but with much slower hydrolysis pharmacokinetics characteristic of prostaglandin N-amides. |
| Molecular Weight | 417.58 |
| Formula | C25H39NO4 |
| Cas No. | 607351-44-0 |
| Smiles | C(C[C@H](CCC1=CC=CC=C1)O)[C@@H]2[C@@H](C/C=C\CCCC(NCC)=O)[C@@H](O)C[C@H]2O |
| Relative Density. | 1.095 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (119.74 mM), Sonication is recommended. DMF: 30 mg/mL (71.84 mM), Sonication is recommended. Ethanol: 30 mg/mL (71.84 mM), Sonication is recommended. PBS (pH 7.2): 200 μg/mL, Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMF/Ethanol/DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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