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Claudin-18 Protein, Human, Recombinant (CLDN18.1)
(Synonyms: SFTPJ, SFTA5, claudin 18) Copy Product InfoSynonyms: SFTPJ, SFTA5, claudin 18
Catalog No. TMPY-06828 Copy Product Info
Claudin-18 Protein, Human, Recombinant (CLDN18.1) is expressed in HEK293 mammalian cells. The predicted molecular weight is 27.86 kDa and the accession number is P56856-1.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 µg | $490 | 7-10 days | 7-10 days | |
| 20 µg | $838 | 7-10 days | 7-10 days | |
| 50 µg | $1,230 | 7-10 days | 7-10 days | |
| 100 µg | $1,930 | 7-10 days | 7-10 days | |
| 200 µg | $2,750 | 7-10 days | 7-10 days | |
| 500 µg | $6,150 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Human Claudin18.1-VLP (Full Length) Protein at 5 μg/mL (100 μL/well) can bind Anti-Human claudin18.1 Antibody, Rabbit IgG1, the EC50 is 0.8 ng/mL (QC tested). |
| Description | Claudin-18 Protein, Human, Recombinant (CLDN18.1) is expressed in HEK293 mammalian cells. The predicted molecular weight is 27.86 kDa and the accession number is P56856-1. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | Tag Free |
| Accession Number | P56856-1 |
| Construction | A DNA sequence encoding the human CLDN18 (P56856-1) (Met1-Val261) was expressed. Predicted N terminal: Met 1 |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Supplied as sterile 50 mM Hepes, 150 mM NaCl 10% Trehalose, pH 7.2. |
| Synonyms | SFTPJ, SFTA5, claudin 18 |
| Research Background | Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, and signaling. CLDN18 deficiency has been associated with atrophic gastritis, spasmolytic polypeptide-expressing metaplasia (SPEM), and asthma. Lung-specific CLDN18.1 modulates alveolar epithelial type II (AT2) cell proliferation and organ size. Restoration of CLDN18.1 expression in human lung cancer cells has been shown to suppress proliferation, inhibiting the IGF-1R/AKT axes. Not expressed in other healthy tissues, gastric mucosa-specific isoform CLDN18.2 expression manifests in primary gastric cancers. CLDN18.2 at the surface of epithelial tumor cells is a target in antibody and CAR-therapies currently in development. |
| Molecular Weight | 27.86 kDa (predicted) |
| Shipping | Proteins are shipped with blue ice. |
| Storage | It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: Claudin-18 Protein, Human, Recombinant (CLDN18.1) chemical structure | Claudin-18 Protein, Human, Recombinant (CLDN18.1) molecular weight
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