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Clorgyline

Name: Clorgyline
Brand: TargetMol
SKU: T70206
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: M&B9302, M&B 9302) Copy Product Info

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Synonyms: M&B9302, M&B 9302

Catalog No. T70206 Copy Product Info

Purity: 98.39%

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Clorgyline (M&B 9302), an irreversible and selective MAO-A inhibitor with the advantages of oral activity and blood-brain barrier permeability, has an antidepressant effect by structurally altering the enzyme through the formation of intermediate radical cations, and reduces 1% fbs-stimulated VSMC (vascular smooth muscle cell) growth.

Cas No. 17780-72-2

Pack Size	Price	USA Stock	Global Stock
10 mg	$38	In Stock	-
25 mg	$76	In Stock	-
50 mg	$123	In Stock	-
100 mg	$197	1-2 weeks	1-2 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.39%

Appearance:Liquid

Color:Transparent

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Clorgyline (M&B 9302), an irreversible and selective MAO-A inhibitor with the advantages of oral activity and blood-brain barrier permeability, has an antidepressant effect by structurally altering the enzyme through the formation of intermediate radical cations, and reduces 1% fbs-stimulated VSMC (vascular smooth muscle cell) growth.
In vitro	Clorgyline is well known as a selective monoamine oxidase A (MAO-A) inhibitor[1].
In vivo	In chick models, intracerebroventricular injection of Clorgyline (81 nmol) significantly suppressed orexin-A (0.2 nmol)-induced arousal behaviors and reduced brain levels of monoamine metabolites (DOPAC and 5-HIAA). This indicates that Clorgyline blocks MAO-A–mediated monoaminergic activity, thereby inhibiting orexin-A’s arousal effects. While Clorgyline alone did not alter food intake, Clorgyline increased 5-HT and decreased 5-HIAA levels, confirming inhibition of serotonin metabolism[1].
Synonyms	M&B9302, M&B 9302

Chemical Properties

Molecular Weight	272.17
Formula	C₁₃H₁₅Cl₂NO
Cas No.	17780-72-2
Smiles	ClC1=CC=C(OCCCN(C)CC#C)C(Cl)=C1

Storage & Solubility Information

Storage

Keep away from moisture Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (918.54 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (12.12 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6742 mL	18.3709 mL	36.7417 mL	183.7087 mL
5 mM	0.7348 mL	3.6742 mL	7.3483 mL	36.7417 mL
10 mM	0.3674 mL	1.8371 mL	3.6742 mL	18.3709 mL
20 mM	0.1837 mL	0.9185 mL	1.8371 mL	9.1854 mL
50 mM	0.0735 mL	0.3674 mL	0.7348 mL	3.6742 mL
100 mM	0.0367 mL	0.1837 mL	0.3674 mL	1.8371 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: Clorgyline chemical structure | Clorgyline in vivo | Clorgyline in vitro | Clorgyline formula | Clorgyline molecular weight