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WL47

Catalog No. T80775

WL47 is a high-affinity ligand for caveolin-1 (CAV1) with a dissociation constant (Kd) of 23 nM, demonstrating potent disruption of CAV1 oligomers. This compound exhibits selectivity for CAV1, with minimal interaction towards BSA, casein, and HEWL. Notably, WL47's molecular structure is 80% smaller than its T20 parent sequence, rendering it a useful tool for investigating caveolin-1 function [1].

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WL47, CAS N/A

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50 mg	Inquiry	Inquiry

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

Caveolin-1 (CAV) is a 22 kDa monotopic membrane protein that spans a single leaflet of the lipid bilayer with both the N- and C-termini facing the cytoplasmic side. CAV oligomerization results in the formation of high molecular weight complexes, which induce membrane curvature to generate 50-100 nm invaginations known as 'caveolae.'

The peptide T20, a 36 amino acid fragment derived from HIV gp41, inhibits viral fusion with CD4+ T-cells. WL47, which is 80% shorter, exhibits a 7500-fold higher affinity than its T20 progenitor. In vitro studies reveal WL47’s interaction with CAV oligomers and contribute a methodology to quantify oligomerization. Using a CAV variant (CAV(FLV)) that forms spontaneous CAV nanoparticles, WL47 is shown to effectively deoligomerize these structures. However, WL47's ability to disrupt oligomerization is contingent on the absence of a reducing agent, indicating a disulfide bond-mediated dimerization is essential for its activity.

Molecular Weight

N/A

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Dose Conversion

You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Molecular Weight Calculator

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

Molecular Weight g/mol

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

WL47 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.