EPCR Protein, Mouse, Recombinant (hFc)

Name: EPCR Protein, Mouse, Recombinant (hFc)
Brand: TargetMol
SKU: TMPY-02489
Rating: 4.5 (1 reviews)

(Synonyms: protein C receptor, endothelial, Epcr, Ccd41, Ccca, AI325044) Copy Product Info

Synonyms: protein C receptor, endothelial, Epcr, Ccd41, Ccca, AI325044

Catalog No. TMPY-02489 Copy Product Info

EPCR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.3 kDa and the accession number is Q64695.

Pack Size	Price	USA Stock	Global Stock
5 µg	$108	7-10 days	7-10 days
10 µg	$178	7-10 days	7-10 days
20 µg	$296	7-10 days	7-10 days
50 µg	$696	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	EPCR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.3 kDa and the accession number is Q64695.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	Q64695
Construction	A DNA sequence encoding the mouse PROCR (Q64695) extracellular domain (Met 1-Ser 214) was fused with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Leu 18
Protein Purity	> 85 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	protein C receptor, endothelial, Epcr, Ccd41, Ccca, AI325044
Research Background	Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels), activated protein C is found mainly near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depending on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, protease-activated receptor-1. To a degree, APC's anticoagulant properties are independent of its cytoprotective ones, in that expression of one pathway is not affected by the existence of the other.

Chemical Properties

Molecular Weight

49.3 kDa (predicted); 65-75 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.