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Spiraeoside
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Catalog No. TN2234Cas No. 20229-56-5
Alias Quercetin 4′-O-glucoside
Spiraeoside (Quercetin 4′-O-glucoside) is a compound that can be extracted from red onion skins. It exhibits antioxidant, anti-allergy, anti-inflammatory, and anti-tumor activities. It protects human myocardial cells from high glucose-induced damage, oxidative stress, and apoptosis by activating the PI3K/Akt/Nrf2 pathway. It also inhibits mast cell activation and IgE-mediated allergic reactions by suppressing phospholipase C-γ-mediated signaling.
Spiraeoside
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Purity: 99.89%
Catalog No. TN2234Alias Quercetin 4′-O-glucosideCas No. 20229-56-5
Spiraeoside (Quercetin 4′-O-glucoside) is a compound that can be extracted from red onion skins. It exhibits antioxidant, anti-allergy, anti-inflammatory, and anti-tumor activities. It protects human myocardial cells from high glucose-induced damage, oxidative stress, and apoptosis by activating the PI3K/Akt/Nrf2 pathway. It also inhibits mast cell activation and IgE-mediated allergic reactions by suppressing phospholipase C-γ-mediated signaling.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $123 | In Stock | In Stock | |
| 5 mg | $297 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.89%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Spiraeoside (Quercetin 4′-O-glucoside) is a compound that can be extracted from red onion skins. It exhibits antioxidant, anti-allergy, anti-inflammatory, and anti-tumor activities. It protects human myocardial cells from high glucose-induced damage, oxidative stress, and apoptosis by activating the PI3K/Akt/Nrf2 pathway. It also inhibits mast cell activation and IgE-mediated allergic reactions by suppressing phospholipase C-γ-mediated signaling. |
| In vitro | Spiraeoside attenuated the high glucose (HG) -induced decline in cell viability and increased levels of the myocardial enzymes lactate dehydrogenase and aspartate aminotransferase in AC16 cells. Spiraeoside protects AC16 cells from HG-induced oxidative stress, cell damage and apoptosis. The protective effect of Spiraeoside is regulated by the PI3K/Akt/Nrf2 signaling pathway. [1] Spiraeoside inhibits IGE-mediated mast cell activation and anaphylaxis by inhibiting PLC-γ2/MAPK signaling in Lyn induced mast cells. [2] |
| In vivo | Spiraeoside (200 mg/kg orally) improved sperm count, motility and testicular morphology in rats. [3] |
| Synonyms | Quercetin 4′-O-glucoside |
| Molecular Weight | 464.38 |
| Formula | C21H20O12 |
| Cas No. | 20229-56-5 |
| Smiles | O=C1C=2C(OC(=C1O)C3=CC(O)=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C=C3)=CC(O)=CC2O |
| Relative Density. | 1.809g/cm3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (21.53 mM), Sonication is recommended.  Ethanol: 10 mg/mL (21.53 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO/Ethanol
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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