Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(Z)-Lanoconazole is the Z configuration of Lanoconazole which used for dermatophytosis and onychomycosis investigation. Lanoconazole inhibits sterol 14-alpha demethylase and blocks fungal membrane ergosterol biosynthesis that interferes with ergosterol biosynthesis. Lanoconazole is a potent and orally active imidazole antifungal agent with a broad spectrum of activity against fungi both in vitro and in vivo [1] [2].
Pack Size | Availability | Price/USD | Quantity |
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2 mg | 5 days | $ 49.00 |
Description | (Z)-Lanoconazole is the Z configuration of Lanoconazole which used for dermatophytosis and onychomycosis investigation. Lanoconazole inhibits sterol 14-alpha demethylase and blocks fungal membrane ergosterol biosynthesis that interferes with ergosterol biosynthesis. Lanoconazole is a potent and orally active imidazole antifungal agent with a broad spectrum of activity against fungi both in vitro and in vivo [1] [2]. |
In vivo | Lanoconazole effectively mitigates TPA-induced irritant dermatitis through a dose-dependent mechanism (treatment applied to the ear; concentrations between 0.3%-3%; over 6 days), by reducing the production of neutrophil chemotactic factors, including keratinocyte-derived chemokine and macrophage inflammatory protein-2, and by inhibiting neutrophil migration to the site of inflammation [2]. Furthermore, when administered orally at doses of 3, 10, or 30 mg/kg once daily for three weeks, lanoconazole significantly hampers the growth of C. neoformans in comparison to a saline control in healthy mice. It also notably decreases the proliferation of C. neoformans in the lungs and brains of MAIDS mice, demonstrating its potent antifungal efficacy [3]. |
Molecular Weight | 319.83 |
Formula | C14H10ClN3S2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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(Z)-Lanoconazole inhibitor inhibit