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CD16/FCGR3 Protein, Mouse, Recombinant (His & Avi), Biotinylated

Catalog No. TMPY-05340
Synonyms: CD16, Fc receptor, IgG, low affinity III

CD16/FCGR3 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24.4 kDa and the accession number is P08508.1.

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CD16/FCGR3 Protein, Mouse, Recombinant (His & Avi), Biotinylated
Pack Size Availability Price/USD Quantity
20 μg 5 days $ 462.00
100 μg 5 days $ 1,070.00
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Biological Description
Technical Params
Product Properties
References and Literature
Description CD16/FCGR3 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24.4 kDa and the accession number is P08508.1.
Species Mouse
Expression System HEK293 Cells
Tag His, Avi
Accession Number P08508.1
Synonyms CD16, Fc receptor, IgG, low affinity III
Construction The Mouse FCGR3 (P08508.1) (Met1-Thr215) was expressed with a c-terminal polyhistidine tagged AVI tag at the C-terminus. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Protein Purity > 95 % as determined by SDS-PAGE.
Molecular Weight 24.4 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background Fc receptors bind the most common class of antibody, IgG, are called Fc gamma receptors (FcγR). FcγR is divided into three classes, Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). CD16 protein is a multifunctional, low/intermediate affinity receptor, which belongs to the immunoglobulin superfamily. It is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. Mouse CD16 is encoded by a single gene, while, human CD16 is expressed as two distinct forms (CD16a/FcγRIIIa and CD16b/FcγRIIIb) encoded by two different highly homologous genes in a cell type-specific manner. CD16 is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), and clearance of immune complexes.

References and Literature

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Keywords

CD16/FCGR3 Protein, Mouse, Recombinant (His & Avi), Biotinylated CD 16 CD16 Fc receptor, IgG, low affinity III CD-16 recombinant recombinant-proteins proteins protein

 

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