Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nepicastat (SYN117) is a selective, potent, and orally active dopamine-beta-hydroxylase inhibitor which can cross the blood-brain barrier (BBB). Nepicastat (SYN117) produces concentration-dependent inhibition of bovine and human dopamine-beta-hydroxylase with IC50s of 8.5 nM and 9 nM [1] [2] [3].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 2,140.00 | |
50 mg | 6-8 weeks | $ 2,785.00 | |
100 mg | 6-8 weeks | $ 3,520.00 |
Description | Nepicastat (SYN117) is a selective, potent, and orally active dopamine-beta-hydroxylase inhibitor which can cross the blood-brain barrier (BBB). Nepicastat (SYN117) produces concentration-dependent inhibition of bovine and human dopamine-beta-hydroxylase with IC50s of 8.5 nM and 9 nM [1] [2] [3]. |
In vivo | Nepicastat, administered orally at doses ranging from 3 to 100 mg/kg at 12-hour intervals for three consecutive doses, elicited dose-dependent reductions in noradrenaline levels while increasing dopamine levels and the dopamine/noradrenaline ratio in the mesenteric or renal arteries, left ventricle, and cerebral cortex of 15-16 week-old male spontaneously hypertensive rats (SHRs). |
Molecular Weight | 295.35 |
Formula | C14H15F2N3S |
CAS No. | 173997-05-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Nepicastat 173997-05-2 inhibitor inhibit