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cRIPGBM chloride

Catalog No. T72658 CAS 2361988-77-2

cRIPGBM chloride is an orally active, proapoptotic compound derived from glioblastoma multiforme (GBM) cancer stem cells (CSCs). It specifically targets receptor-interacting protein kinase 2 (RIPK2) to trigger caspase 1-dependent apoptosis. By inhibiting the formation of the RIPK2/TAK1 prosurvival complex and promoting the assembly of the RIPK2/caspase 1 proapoptotic complex, cRIPGBM chloride efficiently suppresses tumor growth. This action results in significant anti-tumor activity in animal models in vivo.

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cRIPGBM chloride, CAS 2361988-77-2

Pack Size	Availability	Price/USD	Quantity
2 mg	5 days	$ 50.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	446.9
Formula	C26H20ClFN2O2
CAS No.	2361988-77-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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You can also refer to dose conversion for different animals. More

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

cRIPGBM chloride 2361988-77-2 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.