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Isotope productsDeuterium Labeled Compounds
Deuterium (Hydrogen-2) labeled compounds are chemical compounds in which one or more hydrogen atoms are replaced by deuterium, a stable isotope of hydrogen. Deuterium has one proton and one neutron in its nucleus, whereas the most common hydrogen isotope (protium) has only a single proton. Deuterium (Hydrogen-2) labeled compounds can be utilized in studying drug metabolism and reaction kinetics.
JNJ-6204
T695222765264-50-2In house
JNJ-6204 is a dual inhibitor of CSNK1D (IC50 = 2.3 nM) and CSNK1E (IC50 = 137 nM).
- $195
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VX-984
T110671476074-39-1
VX-984 (M9831) is an oral, selective DNA-PK inhibitor that can cross the blood-brain barrier. VX-984 inhibited the conjugation of non-homologous terminal NHEJ and acted on DSBs to break DNA double strand. VX-984 is commonly seen in glioblastoma (GBM) and non-small cell lung cancer (NSC-LC) studies.
- $133
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Fulvestrant-d3
TMIJ-0244
Fulvestrant-d3 is a isotope labeled compound of Fulvestrant.Fulvestrant (ZM 182780) is an estrogen receptor (ER) antagonist and GPR30 agonist that inhibits cell proliferation and induces apoptosis and autophagy.
- Inquiry Price
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Vitamin B3-d4
T8530866148-15-0
Vitamin B3-d4 (Nicotinic acid-(ring-d4)) is the deuterium substitute for Niacin and is used to track Niacin metabolism in the body.
- $73
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Palbociclib-d8
T123551628752-83-9
Palbociclib-d8 (PD 0332991 D8) is the 2H-labeled form of Palbociclib. Palbociclib is an orally active CDK inhibitor that inhibits CDK4 and CDK6 (IC50=11 16 nM). Palbociclib has anti-tumor activity and is used in research for estrogen receptor-positive and HER2-negative breast cancer.
- $489
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Donafenib
T169091130115-44-4
Donafenib (Bay 43-9006 (D3)) is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively).
- $84
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Isoniazid-d4
TMIJ-0309774596-24-6
Isoniazid-d4 is a deuterium isotope marker for Isoniazid, which can be used for isotope tracing and drug metabolism studies.Isoniazid is a prodrug that must be activated by the bacterial peroxidase KatG, and is bactericidal against rapidly dividing Mycobacterium species.
- $330
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5-Hydroxy-L-tryptophan-4,6,7-d3
TMID-01511276197-29-5
5-Hydroxy-L-tryptophan-4,6,7-d3 is L-5-Hydroxytryptophan labeled with 2H. L-5-Hydroxytryptophan (L-5-HTP) is a dietary supplement and a precursor to serotonin, which inhibits the IFN-γ induced PD-L1 expression. It promotes anti-tumor immunity and is used in research on migraine and depression.
- $130
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Corticosterone-d8
TMIH-01671271728-07-4
Corticosterone-d8 is a 2H-labeled corticosteroid, an orally active adrenal corticosteroid with mineralocorticoid and glucocorticoid activity, involved in hormonal regulation in animals.
- $160
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Aniline-d5
TMIJ-03424165-61-1
Aniline-d5 is a deuterated isotope marker of Aniline, which can be used for isotope tracing.Aniline induces toxicity to the spleen through iron overload and oxidative stress via heme oxygenase 1 up-regulation and is able to lead to a significant increase in p-IKKα and p-IKKβ, which in turn increases NF-κB and AP-1 binding activity.
- $31
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Melatonin-d4
T1199566521-38-8
Melatonin D5, a deuterium-labeled version of melatonin, is a hormone produced by the pineal gland, known for its role as a selective ATF-6 inhibitor that promotes apoptosis in human hepatoma cells via COX-2 downregulation. Additionally, it activates melatonin receptors and exhibits antioxidative and anti-inflammatory properties.
- $318
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DL-Metanephrine-d3 Hydrochloride
TMIH-01971085333-94-3
DL-Metanephrine-d3 Hydrochloride is L-Metanephrine labeled with deuterium atoms and can be used to study the metabolic flow of L-Metanephrine in the body.
- $198
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Ursodeoxycholic Acid-d4
TMIH-0590347841-46-7
Ursodeoxycholic Acid-d4 (Ursodeoxycholic acid-2,2,4,4-d4) is the deuterium substitute of Ursodeoxycholic acid, and is an internal standard for the quantitative determination of Ursodeoxycholic Acid (UDCA) levels by LC MS or GC MS.
- $105
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L-838417 D9
T223011213669-91-0
L-838417 D9 (C-21191) is a novel deuterated subtype-selective GABAA positive allosteric modulator, acting as a partial agonist at α2, α3 and α5 subtypes[1].
- $30
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Sulfamethoxazole-d4
T130311020719-86-1
Sulfamethoxazole-d4 (Ro4-2130 D4) is a deuterium labeled Sulfamethoxazole, which can be used for isotope tracing.Sulfamethoxazole is a sulfonamide antimicrobial agent.
- $249
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Vanillin-d3
TMIH-059374495-74-2
Vanillin-d3 (4-Hydroxy-3-methoxybenzaldehyde-d3) is the deuterium marker for vanillin and can be used for isotopic tracing. Vanillin (Zimco) is a natural product extracted from vanilla beans and is commonly used in perfumes, food and pharmaceuticals.
- $64
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Choline-d4 Chloride
TMIH-0149285979-70-6
Choline-d4 Chloride (Choline-1,1,2,2-D4 Chloride) is a deuterated form of Choline chloride, an essential nutrient activating α7 nicotinic receptors with anti-inflammatory and analgesic activity. It impacts atherosclerosis, neurological diseases, and liver diseases.
- $40
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Dimethyl-d6 Sulfoxide
T92422206-27-1
Dimethyl-d6 Sulfoxide is a form in which hydrogen ( H ) of dimethyl sulfoxide (DMSO, (CH3) 2S = O) is replaced by another isotope deuterium ( d ). Dimethyl-d6 Sulfoxide is a common solvent in nuclear magnetic resonance spectroscopy.
- $35
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Zanubrutinib-d5
TMIH-0610
Zanubrutinib-d5 (BGB-3111-d5), a deuterium-labeled Zanubrutinib, is an orally available Bruton's tyrosine kinase inhibitor for the study of B-cell malignancies.
- $514
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Vancomycin-C13,D3
TMID-0283
Vancomycin-C13,D3 is a compound labeled with 13C and 2H. Vancomycin is a glycopeptide antibiotic that exerts antibacterial activity by altering cell membrane permeability and selectively inhibiting RNA synthesis.
- $5,800
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Pivalic acid-d9
TMIJ-004642983-07-3
Pivalic acid-d9 (Trimethyl-d9-acetic acid) is a 2H-labeled version of Pivalic acid, used for synthesizing neopentyl chloride and neopentyl esters.
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Crisaborole-d4
TMIJ-0249
Crisaborole-d4 (AN-2728-d4) is a 2H-labeled version of Crisaborole. Crisaborole is a phosphodiesterase 4 (PDE4) inhibitor and cytokine release inhibitor, used in the study of atopic dermatitis.
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Apalutamide-13C-d3
TMIH-0092
Apalutamide-13C-d3 (RN-509-13C,d3) is a 13C and 2H-labeled version of Apalutamide. Apalutamide is an efficient androgen receptor (AR) antagonist used in the study of prostate diseases.
- $728
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Rivaroxaban-d4
T127361132681-38-9
Rivaroxaban-d4 is a deuterated marker of Rivaroxaban for isotopic tracing.Rivaroxaban (BAY 59-7939) is a highly potent and selective direct inhibitor of coagulation factor Xa (FXa), with an IC50 = 0.7 nM and a Ki of 0.4 nM.
- TBD
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