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BMT-090605 hydrochloride

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Catalog No. T61941Cas No. 2231664-45-0

BMT-090605 hydrochloride is an effective and selective inhibitor of connexin-2 associated kinase 1 (AAK1) (IC50=0.6 nM). BMT-090605 hydrochloride inhibits BMP-2 induced protein kinase (BIKE) (IC50=45 nM) and cyclin G-related kinase GAK (IC50=60 nM). BMT-090605 hydrochloride shows anti-injury activity. BMT-090605 hydrochloride has research value in neuropathic pain.

BMT-090605 hydrochloride
Other Forms of BMT-090605 hydrochloride:
BMT-090605T146911551403-51-0
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BMT-090605 hydrochloride

😃Good
Catalog No. T61941Cas No. 2231664-45-0
BMT-090605 hydrochloride is an effective and selective inhibitor of connexin-2 associated kinase 1 (AAK1) (IC50=0.6 nM). BMT-090605 hydrochloride inhibits BMP-2 induced protein kinase (BIKE) (IC50=45 nM) and cyclin G-related kinase GAK (IC50=60 nM). BMT-090605 hydrochloride shows anti-injury activity. BMT-090605 hydrochloride has research value in neuropathic pain.
Pack SizePriceAvailabilityQuantity
25 mg$1,8108-10 weeks
50 mg$2,3608-10 weeks
100 mg$3,6108-10 weeks
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Product Introduction

Bioactivity
Description
BMT-090605 hydrochloride is an effective and selective inhibitor of connexin-2 associated kinase 1 (AAK1) (IC50=0.6 nM). BMT-090605 hydrochloride inhibits BMP-2 induced protein kinase (BIKE) (IC50=45 nM) and cyclin G-related kinase GAK (IC50=60 nM). BMT-090605 hydrochloride shows anti-injury activity. BMT-090605 hydrochloride has research value in neuropathic pain.
In vitro
BMT-090605 hydrochloride demonstrates significant AAK1 inhibitory activity, exhibiting an IC50 of 0.63 nM [1]. Additionally, it effectively inhibits both BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK), with IC50 values of 45 nM and 60 nM, respectively [1].
In vivo
BMT-090605 hydrochloride (intrathecal; 0.3-3 μg/rat) induces antinociception through AAK1 inhibition in the spinal cord in male Sprague-Dawley rats subjected to chronic constriction injury (CCI) [1]. A dose-dependent decrease in thermal hyperalgesia was observed, demonstrating its efficacy in reducing pain sensations.
Chemical Properties
Molecular Weight400.91
FormulaC21H25ClN4O2
Cas No.2231664-45-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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