Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMT-090605 hydrochloride is an effective and selective inhibitor of connexin-2 associated kinase 1 (AAK1) (IC50=0.6 nM). BMT-090605 hydrochloride inhibits BMP-2 induced protein kinase (BIKE) (IC50=45 nM) and cyclin G-related kinase GAK (IC50=60 nM). BMT-090605 hydrochloride shows anti-injury activity. BMT-090605 hydrochloride has research value in neuropathic pain.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,810.00 | |
50 mg | 8-10 weeks | $ 2,360.00 | |
100 mg | 8-10 weeks | $ 3,610.00 |
Description | BMT-090605 hydrochloride is an effective and selective inhibitor of connexin-2 associated kinase 1 (AAK1) (IC50=0.6 nM). BMT-090605 hydrochloride inhibits BMP-2 induced protein kinase (BIKE) (IC50=45 nM) and cyclin G-related kinase GAK (IC50=60 nM). BMT-090605 hydrochloride shows anti-injury activity. BMT-090605 hydrochloride has research value in neuropathic pain. |
In vitro | BMT-090605 hydrochloride demonstrates significant AAK1 inhibitory activity, exhibiting an IC50 of 0.63 nM [1]. Additionally, it effectively inhibits both BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK), with IC50 values of 45 nM and 60 nM, respectively [1]. |
In vivo | BMT-090605 hydrochloride (intrathecal; 0.3-3 μg/rat) induces antinociception through AAK1 inhibition in the spinal cord in male Sprague-Dawley rats subjected to chronic constriction injury (CCI) [1]. A dose-dependent decrease in thermal hyperalgesia was observed, demonstrating its efficacy in reducing pain sensations. |
Molecular Weight | 400.91 |
Formula | C21H25ClN4O2 |
CAS No. | 2231664-45-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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BMT-090605 hydrochloride 2231664-45-0 inhibitor inhibit