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Ifenprodil
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Catalog No. T1186LCas No. 23210-56-2
Alias RC61-91, RC-61-91, RC 61-91, RC 6191
Ifenprodil (RC61-91) is an inhibitor of the NMDA receptor, specifically of GluN1 (glycine-binding NMDA receptor subunit 1) and GluN2B (glutamate-binding NMDA receptor subunit 2) subunits. Additionally, Ifenprodil inhibits GIRK channels and interacts with alpha1 adrenergic, serotonin, and sigma receptors.
Ifenprodil
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Purity: 99.58%
Catalog No. T1186LAlias RC61-91, RC-61-91, RC 61-91, RC 6191Cas No. 23210-56-2
Ifenprodil (RC61-91) is an inhibitor of the NMDA receptor, specifically of GluN1 (glycine-binding NMDA receptor subunit 1) and GluN2B (glutamate-binding NMDA receptor subunit 2) subunits. Additionally, Ifenprodil inhibits GIRK channels and interacts with alpha1 adrenergic, serotonin, and sigma receptors.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $61 | In Stock | In Stock | |
| 5 mg | $145 | In Stock | In Stock | |
| 10 mg | $219 | In Stock | In Stock | |
| 25 mg | $358 | In Stock | In Stock | |
| 50 mg | $513 | In Stock | In Stock | |
| 100 mg | $710 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $152 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.58%
Appearance:Solid
Color:White
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Product Introduction
Ifenprodil AI Summary
Ifenprodil exhibits a broad spectrum of bioactivities, demonstrating significant interactions with various receptor systems and potential pharmacological effects that span multiple biological pathways and conditions. Key bioactivities include:
- High affinity for sigma1 receptors (Ki = 2.0 nM).
- Potent inhibition of [3H]-ifenprodil from GluN2B NMDA receptors (Ki = 10.0 nM).
- Moderate affinity for sigma2 receptors (Ki = 98.0 nM) and sigma receptor type 2 (Ki = 4.9 nM).
- Antagonistic activity at the N-methyl-D-aspartate (NMDA) receptor subunit NR2B in various assays, with IC50 values ranging from 110.0 nM to 590.0 nM.
- Neuroprotective activity in SH-SY5Y cells against NMDA-induced cell death (IC50 = 0.73 nM).
- Inhibition of sterol delta 8-delta 7 isomerase in guinea pig liver membranes (Ki = 2.71 nM, 4.7 nM, 15.0 nM, and 19.8 nM).
- High binding affinity and antagonistic effect on sigma receptors in rat and guinea pig liver membranes with Ki values including 3.9 nM for sigma receptor (type 2).
- Antiproliferative activities against various cancer cell lines including human PC3 cells (Ki = 25.8 nM) and GBM2 cells (EC50 = 206.0 nM).
- Activity related to sigma receptor modulation with selectivity values and inhibitory concentrations suggesting therapeutic potential.
- Demonstrated capabilities in reducing glutamate-induced neurotoxicity and ischemia-reperfusion injury in various models.
- Potent inhibition effects on human ERG channels (IC50 = 100.0 nM) and multiple receptor targets such as DRD2, HTR1A, SLC6A4, and more, showing binding affinities on the order of low to mid-nano molar ranges (AC50 values).
This extensive bioactivity profile supports the potential of Ifenprodil in addressing diverse therapeutic areas including neuroprotection, antiproliferative therapy, and modulation of neurological receptor systems..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Ifenprodil (RC61-91) is an inhibitor of the NMDA receptor, specifically of GluN1 (glycine-binding NMDA receptor subunit 1) and GluN2B (glutamate-binding NMDA receptor subunit 2) subunits. Additionally, Ifenprodil inhibits GIRK channels and interacts with alpha1 adrenergic, serotonin, and sigma receptors. |
| Synonyms | RC61-91, RC-61-91, RC 61-91, RC 6191 |
| Molecular Weight | 325.44 |
| Formula | C21H27NO2 |
| Cas No. | 23210-56-2 |
| Smiles | C(C1CCN(C(C(O)C2=CC=C(O)C=C2)C)CC1)C3=CC=CC=C3 |
| Relative Density. | 1.14 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 27.5 mg/mL (84.5 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (3.07 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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