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Matrine

🥰Excellent
Catalog No. T2870Cas No. 519-02-8
Alias α-Matrine, Vegard, Matrinium, (+)-Matrine

Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.

Matrine
Other Forms of Matrine:
L-SophoridineT303083148-91-8
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Matrine

🥰Excellent
Purity: 97.16%
Catalog No. T2870Alias α-Matrine, Vegard, Matrinium, (+)-MatrineCas No. 519-02-8
Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$36In StockIn Stock
50 mg$53In StockIn Stock
100 mg$74In StockIn Stock
200 mg$119In StockIn Stock
500 mg$263In StockIn Stock
1 mL x 10 mM (in DMSO)$45In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:97.16%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
In vitro
In human non-small cell lung cancer A549 and hepatocellular carcinoma SMMC-7721 cells, Matrine inhibits cell growth. Particularly, in A549 cells, Matrine induces apoptosis by reducing the Bcl-2 / Bax protein ratio.
In vivo
In mice, the median lethal dose (LD50) of Matrine administered via intraperitoneal injection is 157 mg/kg.
Synonymsα-Matrine, Vegard, Matrinium, (+)-Matrine
Chemical Properties
Molecular Weight248.36
FormulaC15H24N2O
Cas No.519-02-8
SmilesO=C1CCCC2C3CCCN4CCCC(CN12)C34
Relative Density.1.16 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 49 mg/mL (197.29 mM), Sonication is recommended.
H2O: 11 mg/mL (44.29 mM), Heating is recommended.
DMSO: 45 mg/mL (181.19 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.05 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO/Ethanol
1mg5mg10mg50mg
1 mM4.0264 mL20.1321 mL40.2641 mL201.3207 mL
5 mM0.8053 mL4.0264 mL8.0528 mL40.2641 mL
10 mM0.4026 mL2.0132 mL4.0264 mL20.1321 mL
20 mM0.2013 mL1.0066 mL2.0132 mL10.0660 mL
DMSO/Ethanol
1mg5mg10mg50mg
50 mM0.0805 mL0.4026 mL0.8053 mL4.0264 mL
100 mM0.0403 mL0.2013 mL0.4026 mL2.0132 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

κ-opioid receptorOpioidReceptorOpioid ReceptorNon-small cell lung cancerMitophagyMatrinehepatomaFerroptosisAutophagyanti-oxidative stressa-Matrinealpha-Matrineacute kidney injury (AKI) modelA549 cells
Related Tags: buy Matrine | purchase Matrine | Matrine cost | order Matrine | Matrine chemical structure | Matrine in vivo | Matrine in vitro | Matrine formula | Matrine molecular weight
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