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Matrine

Name: Matrine
Brand: TargetMol
SKU: T2870
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2870Cas No. 519-02-8

Alias α-Matrine, Vegard, Matrinium, (+)-Matrine

Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.

Matrine

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Purity: 99.77%

Catalog No. T2870Alias α-Matrine, Vegard, Matrinium, (+)-MatrineCas No. 519-02-8

Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$36	In Stock	In Stock
50 mg	$53	In Stock	In Stock
100 mg	$74	In Stock	In Stock
200 mg	$119	In Stock	In Stock
500 mg	$263	In Stock	-
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.77%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
In vitro	In human non-small cell lung cancer A549 and hepatocellular carcinoma SMMC-7721 cells, Matrine inhibits cell growth. Particularly, in A549 cells, Matrine induces apoptosis by reducing the Bcl-2 / Bax protein ratio.
In vivo	In mice, the median lethal dose (LD50) of Matrine administered via intraperitoneal injection is 157 mg/kg.
Synonyms	α-Matrine, Vegard, Matrinium, (+)-Matrine

Chemical Properties

Molecular Weight	248.36
Formula	C₁₅H₂₄N₂O
Cas No.	519-02-8
Smiles	O=C1CCCC2C3CCCN4CCCC(CN12)C34
Relative Density.	1.16 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 49 mg/mL (197.29 mM), Sonication is recommended.

H2O: 20 mg/mL (80.53 mM), Sonication is recommended.

DMSO: 45 mg/mL (181.19 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.05 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	4.0264 mL	20.1321 mL	40.2641 mL	201.3207 mL
5 mM	0.8053 mL	4.0264 mL	8.0528 mL	40.2641 mL
10 mM	0.4026 mL	2.0132 mL	4.0264 mL	20.1321 mL
20 mM	0.2013 mL	1.0066 mL	2.0132 mL	10.0660 mL
50 mM	0.0805 mL	0.4026 mL	0.8053 mL	4.0264 mL

DMSO/Ethanol

	1mg	5mg	10mg	50mg
100 mM	0.0403 mL	0.2013 mL	0.4026 mL	2.0132 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc