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LILRB2/CD85d/ILT4 Protein, Human, Recombinant (Avi & His), Biotinylated

Catalog No. TMPJ-00552
Synonyms: Leukocyte Immunoglobulin-Like Receptor 2, Monocyte/Macrophage Immunoglobulin-Like Receptor 10, MIR-10, CD85 Antigen-Like Family Member D, Immunoglobulin-Like Transcript 4, ILT-4, L, Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2, LIR-2, CD85d

Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa transmenbrane segment, and a 116 aa cytoplasmic domain. LIR-2 binds to Classical MHCI proteins. Ligation of LIR-2 incluces Tyr phosphorylation within its cytoplasmic ITIMs, a requirement for association with SHP-1. LIR-2 mediates tolerogenic DC-induced CD4+ T cell energy in vitro and in vivo.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
LILRB2/CD85d/ILT4 Protein, Human, Recombinant (Avi & His), Biotinylated
Pack Size Availability Price/USD Quantity
20 μg 5 days $ 355.00
100 μg 5 days $ 963.00
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Biological Description
Technical Params
Product Properties
Description Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa transmenbrane segment, and a 116 aa cytoplasmic domain. LIR-2 binds to Classical MHCI proteins. Ligation of LIR-2 incluces Tyr phosphorylation within its cytoplasmic ITIMs, a requirement for association with SHP-1. LIR-2 mediates tolerogenic DC-induced CD4+ T cell energy in vitro and in vivo.
Species Human
Expression System HEK293 Cells
Tag C-Avi-6xHis
Accession Number AAH36827.1
Synonyms Leukocyte Immunoglobulin-Like Receptor 2, Monocyte/Macrophage Immunoglobulin-Like Receptor 10, MIR-10, CD85 Antigen-Like Family Member D, Immunoglobulin-Like Transcript 4, ILT-4, L, Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2, LIR-2, CD85d
Amino Acid Gln22-His458
Construction Gln22-His458
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 60-80 KDa (reducing condition)
Endotoxin < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4.
Reconstitution Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa transmenbrane segment, and a 116 aa cytoplasmic domain. LIR-2 binds to Classical MHCI proteins. Ligation of LIR-2 incluces Tyr phosphorylation within its cytoplasmic ITIMs, a requirement for association with SHP-1. LIR-2 mediates tolerogenic DC-induced CD4+ T cell energy in vitro and in vivo.

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Keywords

LILRB2/CD85d/ILT4 Protein, Human, Recombinant (Avi & His), Biotinylated Leukocyte Immunoglobulin-Like Receptor 2 Monocyte/Macrophage Immunoglobulin-Like Receptor 10 MIR-10 MIR 10 CD85 Antigen-Like Family Member D Immunoglobulin-Like Transcript 4 MIR10 ILT-4 ILT4 L ILT 4 LIR 2 Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 LIR2 LIR-2 CD85d recombinant recombinant-proteins proteins protein

 

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