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LILRB2/CD85d/ILT4 Protein, Human, Recombinant (Avi & His), Biotinylated
(Synonyms: Monocyte/Macrophage Immunoglobulin-Like Receptor 10, MIR-10, LIR-2, Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2, Leukocyte Immunoglobulin-Like Receptor 2, L, Immunoglobulin-Like Transcript 4, ILT-4, CD85d, CD85 Antigen-Like Family Member D) Copy Product InfoSynonyms: Monocyte/Macrophage Immunoglobulin-Like Receptor 10, MIR-10, LIR-2, Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2, Leukocyte Immunoglobulin-Like Receptor 2, L, Immunoglobulin-Like Transcript 4, ILT-4, CD85d, CD85 Antigen-Like Family Member D
Catalog No. TMPJ-00552 Copy Product Info
Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa transmenbrane segment, and a 116 aa cytoplasmic domain. LIR-2 binds to Classical MHCI proteins. Ligation of LIR-2 incluces Tyr phosphorylation within its cytoplasmic ITIMs, a requirement for association with SHP-1. LIR-2 mediates tolerogenic DC-induced CD4+ T cell energy in vitro and in vivo.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $129 | 35 days | 35 days | |
| 10 μg | $213 | 35 days | 35 days | |
| 20 μg | $355 | 35 days | 35 days | |
| 50 μg | $625 | 35 days | 35 days | |
| 100 μg | $963 | 35 days | 35 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa transmenbrane segment, and a 116 aa cytoplasmic domain. LIR-2 binds to Classical MHCI proteins. Ligation of LIR-2 incluces Tyr phosphorylation within its cytoplasmic ITIMs, a requirement for association with SHP-1. LIR-2 mediates tolerogenic DC-induced CD4+ T cell energy in vitro and in vivo. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-Avi-6xHis |
| Accession Number | AAH36827.1 |
| Amino Acid | Gln22-His458 |
| Construction | Gln22-His458 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | Monocyte/Macrophage Immunoglobulin-Like Receptor 10, MIR-10, LIR-2, Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2, Leukocyte Immunoglobulin-Like Receptor 2, L, Immunoglobulin-Like Transcript 4, ILT-4, CD85d, CD85 Antigen-Like Family Member D |
| Research Background |
| Molecular Weight | 60-80 KDa (reducing condition) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: LILRB2/CD85d/ILT4 Protein, Human, Recombinant (Avi & His), Biotinylated chemical structure | LILRB2/CD85d/ILT4 Protein, Human, Recombinant (Avi & His), Biotinylated molecular weight
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