Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PROTAC BRD4 Degrader-16 is a potent degrader of BRD4, exhibiting IC50 values of 34.58 nM for BRD4 (BD1) and 40.23 nM for BRD4 (BD2). It significantly reduces Cyclin B1 expression, thereby impeding G2/M phase progression, and induces apoptosis in MV-4-11 cells [1].
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Description | PROTAC BRD4 Degrader-16 is a potent degrader of BRD4, exhibiting IC50 values of 34.58 nM for BRD4 (BD1) and 40.23 nM for BRD4 (BD2). It significantly reduces Cyclin B1 expression, thereby impeding G2/M phase progression, and induces apoptosis in MV-4-11 cells [1]. |
In vitro | PROTAC BRD4 Degrader-16 (compound 7f) (100 nM, 4-24 h) significantly induced the degradation of both BRD4 L and BRD4 S in MV-4-11 cells at 100 nM concentration after 4 hours, with BRD4 S levels subsequently returning to baseline by 24 hours, similar to dBET6 [1]. |
Molecular Weight | 819.86 |
Formula | C46H41N7O8 |
CAS No. | 2585561-36-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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PROTAC BRD4 Degrader-16 2585561-36-8 PROTAC PROTACs inhibitor inhibit