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Synonyms: BPS-804, BPS804, BPS 804
Setrusumab

| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $328 | - | In Stock | |
| 5 mg | $993 | - | In Stock | |
| 10 mg | $1,570 | - | In Stock | |
| 25 mg | $2,890 | - | In Stock | |
| 50 mg | $4,650 | - | In Stock |
| Description | Setrusumab (BPS 804) is a fully humanized monoclonal antibody targeting sclerostin, effectively enhancing bone strength. Setrusumab (BPS 804) is used in skeletal biology and bone remodeling research systems to investigate Wnt signaling regulation via sclerostin inhibition, osteoblast activity modulation, and bone density regulation mechanisms in osteogenesis-related disease models including osteogenesis imperfecta (OI) and cancer-associated bone remodeling contexts. |
| In vivo | Method: In vivo administration of Setrusumab was performed in a breast cancer-induced bone metastasis and muscle weakness mouse model. Result: Setrusumab (100 mg/kg, intravenous injection, once weekly for 4 weeks) inhibited bone metastasis and reduced muscle weakness in mice. |
| Synonyms | BPS-804, BPS804, BPS 804 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | sclerostin |
| Cas No. | 1847394-95-9 |
| Isotype | Human lgG2 lambda |
| Storage | Store at low temperature, -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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