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PF07104091

Name: PF07104091
Brand: TargetMol
SKU: T9712
Price: 372 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9712Cas No. 2460249-19-6

Alias PF-07104091

PF07104091 inhibits CDK2, which may lead to cell cycle arrest, induce apoptosis and inhibit tumor cell proliferation.[1]

PF07104091

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Purity: 99.59%

Catalog No. T9712Alias PF-07104091Cas No. 2460249-19-6

PF07104091 inhibits CDK2, which may lead to cell cycle arrest, induce apoptosis and inhibit tumor cell proliferation.[1]

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$372	In Stock	In Stock
2 mg	$546	In Stock	In Stock
5 mg	$867	In Stock	In Stock
10 mg	$1,270	In Stock	In Stock
25 mg	$1,890	In Stock	In Stock
50 mg	$2,550	-	In Stock
100 mg	$3,430	-	In Stock
1 mL x 10 mM (in DMSO)	$963	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.59%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PF07104091 inhibits CDK2, which may lead to cell cycle arrest, induce apoptosis and inhibit tumor cell proliferation.[1]
In vitro	PF-07104091 hydrate (Example 13) inhibits CDK1/cyclin A2, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9, with Kis of 110, 238, 465 and 117 nM.[1] METHODS: We explored whether CDK2 activity could be completely abolished by pharmacological treatment with supraphysiological doses of PF3600 (10 μM) or PF4091 (20 μM). RESULTS We observed an immediate collapse of the DHB reporter signal below the mitotic nadir, without a hump. [2]
Synonyms	PF-07104091

Chemical Properties

Molecular Weight	404.46
Formula	C₁₉H₂₈N₆O₄
Cas No.	2460249-19-6
Smiles	N(C(=O)C1=CC(COC)=NN1C)C2=CC(=NN2)[C@@H]3C[C@H](OC(NC(C)C)=O)CC3
Relative Density.	1.38 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (135.98 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4724 mL	12.3622 mL	24.7243 mL	123.6216 mL
5 mM	0.4945 mL	2.4724 mL	4.9449 mL	24.7243 mL
10 mM	0.2472 mL	1.2362 mL	2.4724 mL	12.3622 mL
20 mM	0.1236 mL	0.6181 mL	1.2362 mL	6.1811 mL
50 mM	0.0494 mL	0.2472 mL	0.4945 mL	2.4724 mL
100 mM	0.0247 mL	0.1236 mL	0.2472 mL	1.2362 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc