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Methylatropine (nitrate)

Catalog No. T36204 CAS 52-88-0

Methylatropine is an antagonist of muscarinic acetylcholine receptors (IC50= <0.1 nM in a radioligand binding assay using isolated porcine brain membranes) and a derivative of atropine .1,2It reduces acetylcholine-induced decreases in blood pressure in rats when administered intravenously with an ED50value of 5.5 μg/kg.2Methylatropine reduces salivation, induces mydriasis, and increases heart rate in dogs.3

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Methylatropine (nitrate) Chemical Structure

Methylatropine (nitrate), CAS 52-88-0

Pack Size	Availability	Price/USD
5 mg	35 days	$ 170.00
25 mg	35 days	$ 463.00
50 mg	35 days	$ 838.00
100 mg	35 days	$ 1,500.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	366.414
Formula	C18H26N2O6
CAS No.	52-88-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 30 mg/mL

DMSO: 30 mg/mL

DMF: 30 mg/mL

PBS (pH 7.2): 10 mg/mL

References and Literature

1. Schmeller, T., Sporer, F., Sauerwein, M., et al.Binding of tropane alkaloids to nicotinic and muscarinic acetylcholine receptorsPharmazie50(7)493-495(1995) 2. Brezenoff, H.E., Xiao, Y.-F., and Vargas, H.A comparison of the central and peripheral antimuscarinic effects of atropine and methylatropine injected systemically and into the cerebral ventriclesLife Sci.42(8)905-911(1988) 3. Albanus, L.Central and peripheral effects of anticholinergic compoundsActa Pharmacol. Toxicol. (Copenh)28(4)305-326(1970)

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Keywords

Methylatropine (nitrate) 52-88-0 Methylatropine inhibitor inhibit

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