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Ganglioside GM2

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Catalog No. T82340Cas No. 127663-77-8

Ganglioside GM2 is a component of the cell membrane's glycosphingolipid bilayer and a human tumor antigen (OFA-I-1). It accumulates and increases in models of Sandhoff disease, Niemann-Pick disease, and Tay-Sachs disease, among others. Ganglioside GM2 binds to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, thereby promoting tumor cell migration and invasion.

Ganglioside GM2

Ganglioside GM2

😃Good
Catalog No. T82340Cas No. 127663-77-8
Ganglioside GM2 is a component of the cell membrane's glycosphingolipid bilayer and a human tumor antigen (OFA-I-1). It accumulates and increases in models of Sandhoff disease, Niemann-Pick disease, and Tay-Sachs disease, among others. Ganglioside GM2 binds to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, thereby promoting tumor cell migration and invasion.
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Product Introduction

Bioactivity
Description
Ganglioside GM2 is a component of the cell membrane's glycosphingolipid bilayer and a human tumor antigen (OFA-I-1). It accumulates and increases in models of Sandhoff disease, Niemann-Pick disease, and Tay-Sachs disease, among others. Ganglioside GM2 binds to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, thereby promoting tumor cell migration and invasion.
In vitro
Ganglioside GM2 (25 μM, 24 hours) significantly enhances the migration and invasion capabilities of SK-RC-45 tumor cells [1].
Chemical Properties
Molecular Weight1384.68
FormulaC67H121N3O26
Cas No.127663-77-8
SmilesO([C@@]1(C(O)=O)O[C@@]([C@@H]([C@@H](CO)O)O)([C@H](NC(C)=O)[C@@H](O)C1)[H])[C@H]2[C@@H](O[C@H]3[C@H](NC(C)=O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)[C@@H](CO)O[C@@H](O[C@@H]4[C@@H](CO)O[C@@H](OC[C@H](NC(CCCCCCCCCCCCCCCCC)=O)[C@@H](/C=C/CCCCCCCCCCCCC)O)[C@H](O)[C@H]4O)[C@@H]2O
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 10 mg/mL (7.22 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.7222 mL3.6109 mL7.2219 mL36.1094 mL
5 mM0.1444 mL0.7222 mL1.4444 mL7.2219 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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