Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dobutamine is a synthetic catecholamine that can increase cardiac output and correct hypoperfusion. Dobutamine acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors) that is a selective agonist of β1-AR , relatively weak activity at α1-AR and β2-AR. [1] [2] [3] [4].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Dobutamine is a synthetic catecholamine that can increase cardiac output and correct hypoperfusion. Dobutamine acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors) that is a selective agonist of β1-AR , relatively weak activity at α1-AR and β2-AR. [1] [2] [3] [4]. |
In vivo | Dobutamine rapidly initiates action and possesses a short half-life. Administered intraperitoneally at dosages ranging from 0.15 to 20 mg/kg, it enhances left ventricular function and escalates heart rate in wildtype mice, with effects intensifying at higher doses. At elevated doses, dobutamine significantly amplifies inotropic (force of heart's contraction), lusitropic (relaxation of cardiac muscles), and chronotropic (rate of heartbeat) responses in these mice. Conversely, low doses markedly improve inotropic and lusitropic functions without affecting heart rate in Tgαq*44 mice, models of heart failure, indicating a dose-dependent variability in cardiac response. However, beyond certain dosages, dobutamine increases heart rate without improving cardiac functional reserve, underlining a lost benefit in heart function at high doses. Additionally, dobutamine has been shown to increase alveolar liquid clearance in ventilated rats through beta-2 receptor stimulation, showcasing its potential benefits beyond cardiac applications. |
Molecular Weight | 301.38 |
Formula | C18H23NO3 |
CAS No. | 34368-04-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Dobutamine 34368-04-2 inhibitor inhibit