IL-17RA Protein, Human, Recombinant (hFc & Avi), Biotinylated

Catalog No. TMPY-06390

IL-17RA Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 61.99 kDa and the accession number is Q96F46-1.

IL-17RA Protein, Human, Recombinant (hFc & Avi), Biotinylated

Catalog No. TMPY-06390

Pack Size	Price	Availability	Quantity
20 μg	$462	In Stock
100 μg	$1,070	7-10 days

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COA User Guide of Recombinant Proteins

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Product Information

Biological Activity	Immobilized Human IL17 at 2 μg/mL (100 μL/well) can bind Human IL17RA (hFc & AVI Tag), Biotinylated, the EC50 of Human IL17RA (hFc & AVI Tag), Biotinylated is 50-400 ng/mL.
Description	IL-17RA Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 61.99 kDa and the accession number is Q96F46-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc-Avi
Accession Number	Q96F46-1
Synonyms	interleukin 17 receptor A,IL-17RA,IL17R,hIL-17R,CDw217,CD217,CANDF5
Construction	A DNA sequence encoding the human IL17RA (NP_055154.3)(Met1-Trp320) was expressed with a c-terminal AVI tagged Fc region of human IgG1 at the C-terminus (Fc-AVI). The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed. Predicted N terminal: Leu 33
Protein Purity	> 95 % as determined by SDS-PAGE.
Molecular Weight	61.99 kDa (predicted); 89.18 kDa (reducing conditions)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor that binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails, and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.