Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 107.00 | |
10 mg | Inquiry | $ 172.00 | |
50 mg | Inquiry | $ 504.00 | |
100 mg | Inquiry | $ 873.00 |
Description | TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. |
In vitro | TAS-103 acts as a dual inhibitor of DNA topoisomerase I and II, demonstrating potency across various cell lines. Specifically, it shows activity against CCRF-CEM cells within a concentration range of 0.1-10 μM, achieving an IC50 of 5 nM, and notably enhances topo IIα FITC immunofluorescence at a concentration of 0.1 μM[1]. It exhibits pronounced cytotoxic effects on Lewis lung carcinoma (LLC) cells across a 0.01-1 μM concentration range, with both its liposomal and free forms displaying nearly equivalent activity[2]. Additionally, TAS-103, at an IC50 of 40 nM, significantly reduces the viability of HeLa cells. At a concentration of 10 μM, it interferes with signal recognition particle (SRP) complex formation, leading to the destabilization and degradation of SRP14 and SRP19 proteins[3]. |
In vivo | TAS-103 (30 mg/kg, i.v.) significantly suppresses tumor growth in mice with Lewis lung carcinoma (LLC) cells without causing noticeable loss of body weight. Furthermore, liposomal TAS-103 demonstrates greater efficacy than its free form[2]. |
Cell Research | CCRF-CEM human acute lymphoblastic leukaemia cells are grown in RPMI-1640 supplemented with 3 mM l-glutamine, 10% foetal bovine serum, 50 U/mL of penicillin, and 40 μg/mL of streptomycin at 37°C in a humidified atmosphere containing 5% CO2. TAS-103, CPT and DACA are dissolved in DMSO. Exponentially growing cells (~5 × 105) are exposed to either of the drugs for 2 hrs. Following drug exposure, cells are washed twice by centrifugation (400 × g, 3 min) in cold phosphate-buffered saline[1]. |
Molecular Weight | 333.391 |
Formula | C20H19N3O2 |
CAS No. | 174634-08-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
You can also refer to dose conversion for different animals. More
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TAS-103 174634-08-3 TAS 103 TAS103 inhibitor inhibit