Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Antimalarial agent 26, a derivative of 1,4-naphthoquinones, demonstrates antimalarial properties through oral administration. It exhibits cytotoxic effects on P. falciparum while maintaining selectivity against mammalian cell lines and effectively inhibits P. berghei-induced parasitemia in vivo [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Antimalarial agent 26, a derivative of 1,4-naphthoquinones, demonstrates antimalarial properties through oral administration. It exhibits cytotoxic effects on P. falciparum while maintaining selectivity against mammalian cell lines and effectively inhibits P. berghei-induced parasitemia in vivo [1]. |
In vitro | Antimalarial agent 26 (compound 11) exhibits an IC50 of 2.7 μM against P. falciparum, with cytotoxicity (CC50) in mammalian cells measured at 440.9 μM for HepG2 and 1336 μM for Vero [1]. Additionally, antimalarial agent 26, at concentrations ranging from 250 to 15.6 μM and applied for 2 hours, demonstrates hemolytic activity below 40% [1]. |
In vivo | Antimalarial agent 26 (compound 11) demonstrated antiplasmodial activity at a dosage of 30 mg/kg, administered orally once daily over four consecutive days, in female albino Swiss mice [1]. Furthermore, a single oral dose of 300 mg/kg of antimalarial agent 26 resulted in hepatocellular damage in female mice [1]. |
Molecular Weight | 366.41 |
Formula | C20H22N4O3 |
CAS No. | 2299199-56-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Antimalarial agent 26 2299199-56-5 Microbiology/Virology Parasite inhibitor inhibit