(Rac)-Lanicemine

Name: (Rac)-Lanicemine
Brand: TargetMol
SKU: T60235
Rating: 4.5 (1 reviews)

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Catalog No. T60235Cas No. 61890-25-3

(Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker with a Ki of 0.56-2.1 μM for the NMDA receptor and IC50 values of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively. Lanicemine shows antidepressant effects [1].

(Rac)-Lanicemine

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Catalog No. T60235Cas No. 61890-25-3

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Product Introduction

Bioactivity

Description

In vivo

Lanicemine demonstrates enduring antidepressant effects while inducing minimal psychotomimetic side effects [1]. When administered intraperitoneally at doses of 3, 10, or 30 mg/kg, lanicemine not only activates brain circuits relevant to the production of gamma-band electroencephalography (EEG) signals but also modulates these networks without causing the widespread disturbances in brain function often associated with ketamine [1]. In a study involving male Sprague-Dawley rats, lanicemine was shown to significantly elevate spontaneous gamma-band EEG activities in a dose-dependent manner, distinguishing it from ketamine, whose effects on gamma EEG changes were closely linked with increased locomotor activity [1].

Chemical Properties

Molecular Weight	198.26
Formula	C₁₃H₁₄N₂
Cas No.	61890-25-3
Smiles	NC(Cc1ccccn1)c1ccccc1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc