Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker with Ki of 0.56-2.1 μM for NMDA receptor; IC 50 s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively. Lanicemine shows antidepressant effects [1].
Description | (Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker with Ki of 0.56-2.1 μM for NMDA receptor; IC 50 s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively. Lanicemine shows antidepressant effects [1]. |
In vivo | Lanicemine demonstrates enduring antidepressant effects while inducing minimal psychotomimetic side effects [1]. When administered intraperitoneally at doses of 3, 10, or 30 mg/kg, lanicemine not only activates brain circuits relevant to the production of gamma-band electroencephalography (EEG) signals but also modulates these networks without causing the widespread disturbances in brain function often associated with ketamine [1]. In a study involving male Sprague-Dawley rats, lanicemine was shown to significantly elevate spontaneous gamma-band EEG activities in a dose-dependent manner, distinguishing it from ketamine, whose effects on gamma EEG changes were closely linked with increased locomotor activity [1]. |
Molecular Weight | 198.26 |
Formula | C13H14N2 |
CAS No. | 61890-25-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
(Rac)-Lanicemine 61890-25-3 inhibitor inhibit