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Guggulsterone

🥰Excellent
Catalog No. T5574Cas No. 95975-55-6
Alias Guggulsterone E&Z

Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.

Guggulsterone
Other Forms of Guggulsterone:

Guggulsterone

🥰Excellent
Purity: 99.8%
Catalog No. T5574Alias Guggulsterone E&ZCas No. 95975-55-6
Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$30In StockIn Stock
5 mg$48In StockIn Stock
10 mg$89In StockIn Stock
25 mg$163In StockIn Stock
50 mg$228In StockIn Stock
100 mg$322In StockIn Stock
200 mg$479In StockIn Stock
1 mL x 10 mM (in DMSO)$53In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.8%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.
In vivo
Guggulsterone E&Z inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP, and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases, inhibition of Akt, and activation of JNK.?Guggulsterone E&Z modulates the expression of gene products involved in metastasis (MMP-9, COX-2, and VEGF) of tumor cells.
SynonymsGuggulsterone E&Z
Chemical Properties
Molecular Weight312.45
FormulaC21H28O2
Cas No.95975-55-6
SmilesC[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=O)CC4)(CC1)[H])[H])(CC(=O)C2=CC)[H]
Relative Density.1.1 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 22.73 mg/mL (72.75 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 1 mg/mL (3.2 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2005 mL16.0026 mL32.0051 mL160.0256 mL
5 mM0.6401 mL3.2005 mL6.4010 mL32.0051 mL
10 mM0.3201 mL1.6003 mL3.2005 mL16.0026 mL
20 mM0.1600 mL0.8001 mL1.6003 mL8.0013 mL
50 mM0.0640 mL0.3201 mL0.6401 mL3.2005 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Z/E-GuggulsteroneJNKGuggulsteroneFXRCaspaseAutophagyApoptosisAkt
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