Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Eudebeiolide B, isolated from Salvia plebeia R. Br., impedes osteoclastogenesis by modulating RANKL-induced NF-κB, c-Fos, and calcium signaling pathways, and is applicable in the study of osteoclast-related diseases [1].
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Description | Eudebeiolide B, isolated from Salvia plebeia R. Br., impedes osteoclastogenesis by modulating RANKL-induced NF-κB, c-Fos, and calcium signaling pathways, and is applicable in the study of osteoclast-related diseases [1]. |
In vitro | Eudebeiolide B (1-30 μΜ, 1 hour) inhibits RANKL-induced cellular differentiation in murine bone marrow-derived macrophages, suppressing the expression of osteoclastogenesis-related marker genes and RANKL-mediated cell signaling [1]. |
In vivo | Eudebeiolide B (5 or 10 mg/kg, administered orally once a day for 6 weeks) prevented bone loss in an ovariectomized (OVX) mouse model caused by bilateral ovariectomy (OVX) [1]. |
Synonyms | Plebeiolide D |
Molecular Weight | 262.3 |
Formula | C15H18O4 |
CAS No. | 1934299-51-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Eudebeiolide B 1934299-51-0 NF-Κb NF-κB Plebeiolide D inhibitor inhibit