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BI 7446

Catalog No. T79313 CAS 2767011-00-5

BI 7446 is a potent and selective cyclic dinucleotide (CDN)-based stimulator of interferon genes (STING) agonist capable of activating all five STING variants in cells, thus inducing tumor-specific immune-mediated tumor rejection. This compound is utilized in immuno-oncology research [1].

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BI 7446, CAS 2767011-00-5

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Description	BI 7446 is a potent and selective cyclic dinucleotide (CDN)-based stimulator of interferon genes (STING) agonist capable of activating all five STING variants in cells, thus inducing tumor-specific immune-mediated tumor rejection. This compound is utilized in immuno-oncology research [1].
In vitro	BI 7446 (CDN13) at concentrations of 3 μM and 10 μM over 6 hours enhances the phosphorylation of IRF3 and TBK1 in THP1 STING wild-type cells [1].
In vivo	BI 7446 (CDN13) administered intravenously at doses of 4, 12, and 36 μg with detection time points up to 25 hours exhibited high plasma clearance and a short elimination half-life in the 4T1 tumor mouse model [1]. Similarly, subcutaneous injections of BI 7446 at 0.25, 1, and 4 μg once weekly resulted in tumor regression in the EMT breast cancer mouse model and generated long-term immune memory against autologous tumor rechallenge [1].

Molecular Weight	693.52
Formula	C20H22FN9O10P2S2
CAS No.	2767011-00-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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STING (WT/R232) activity regulator 126 STING-IN-3 Vadimezan SN-008 ChX710 SAP-04 diABZI STING agonist-1 (Tautomerism) SN-011

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BI 7446 2767011-00-5 Immunology/Inflammation STING inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.