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Teplizumab
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Catalog No. T76763Cas No. 876387-05-2
Alias PRV-031, MGA-031
Teplizumab (MGA-031) is a humanized monoclonal antibody targeting CD3 that slows the loss of beta cell function and is used to treat type 1 diabetes.
Teplizumab
🥰Excellent
Catalog No. T76763Alias PRV-031, MGA-031Cas No. 876387-05-2
Teplizumab (MGA-031) is a humanized monoclonal antibody targeting CD3 that slows the loss of beta cell function and is used to treat type 1 diabetes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $228 | In Stock | |
| 5 mg | $579 | In Stock | |
| 10 mg | $928 | In Stock | |
| 25 mg | $1,370 | In Stock | |
| 50 mg | $1,850 | In Stock |
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Concentration:2.35 mg/mL
Purity:> 95.8% (SDS-PAGE); 99.7% (SEC-HPLC)
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Product Introduction
Bioactivity
Chemical Properties
| Description | Teplizumab (MGA-031) is a humanized monoclonal antibody targeting CD3 that slows the loss of beta cell function and is used to treat type 1 diabetes. |
| In vitro | Teplizumab induces human CD8+ T-cell proliferation (10 ng/mL-10 μg/mL, 5 days)[3]. Teplizumab increases the expression of CD25 and intracellular CTLA4 on CD8+ cells (freshly isolated PBMCs) after 6 days[2]. |
| In vivo | In NSG mice, Teplizumab (0.24 mg/kg, i.p.) induces migration of human CD4 T cells to the lamina propria and ablates the treatment effects of the drug on graft survival[3]. |
| Synonyms | PRV-031, MGA-031 |
| Molecular Weight | 145.79 kDa |
| Cas No. | 876387-05-2 |
| Color | Transparent |
| Appearance | Liquid |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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