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Teplizumab (Synonyms: PRV-031, MGA-031)
Catalog No. T76763 Copy Product Info
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Teplizumab (MGA-031) is a humanized monoclonal antibody targeting CD3 that slows the loss of beta cell function and is used to treat type 1 diabetes.
Teplizumab
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Catalog No. T76763
Synonyms PRV-031, MGA-031
Teplizumab (MGA-031) is a humanized monoclonal antibody targeting CD3 that slows the loss of beta cell function and is used to treat type 1 diabetes.
Cas No. 876387-05-2
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $228 | In Stock | In Stock | |
| 5 mg | $579 | In Stock | In Stock | |
| 10 mg | $928 | - | In Stock | |
| 25 mg | $1,370 | - | In Stock | |
| 50 mg | $1,850 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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Purity:> 95.8% (SDS-PAGE); 99.7% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Teplizumab (MGA-031) is a humanized monoclonal antibody targeting CD3 that slows the loss of beta cell function and is used to treat type 1 diabetes. |
| In vitro | Teplizumab induces human CD8+ T-cell proliferation (10 ng/mL-10 μg/mL, 5 days)[3]. Teplizumab increases the expression of CD25 and intracellular CTLA4 on CD8+ cells (freshly isolated PBMCs) after 6 days[2]. |
| In vivo | In NSG mice, Teplizumab (0.24 mg/kg, i.p.) induces migration of human CD4 T cells to the lamina propria and ablates the treatment effects of the drug on graft survival[3]. |
| Synonyms | PRV-031, MGA-031 |
| Reactivity | Human |
| Verified Activity | Immobilized Human CD3D & CD3E Protein (Flag & His) (TMPY-03745) at 1 μg/mL (100 μL/well) can bind Teplizumab. The EC50 is 8.32 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | CD3e |
| Molecular Weight | 145.79 kDa |
| Cas No. | 876387-05-2 |
| Isotype | IgG1 |
| Storage | -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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