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Preclamol hydrochloride (Synonyms: (-)-3-PPP hydrochloride)

Name: Preclamol hydrochloride
Brand: TargetMol
SKU: T73684
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Preclamol hydrochloride ((-)-3-PPP hydrochloride) is a selective dopamine autoreceptor agonist. It functions by specifically activating presynaptic autoreceptors, which triggers a negative feedback loop to inhibit the synthesis and release of dopamine. Unlike conventional neuroleptics that primarily block postsynaptic receptors, Preclamol offers a more refined modulation of the dopaminergic system. This unique pharmacological profile makes it a valuable tool in schizophrenia research, aiming to alleviate psychotic symptoms with a potentially lower risk of extrapyramidal side effects.

Preclamol hydrochloride

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Catalog No. T73684

Synonyms (-)-3-PPP hydrochloride

Cas No. 88768-67-6

Pack Size	Price	USA Stock	Global Stock	Quantity
2 mg	$29	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description	Preclamol hydrochloride ((-)-3-PPP hydrochloride) is a selective dopamine autoreceptor agonist. It functions by specifically activating presynaptic autoreceptors, which triggers a negative feedback loop to inhibit the synthesis and release of dopamine. Unlike conventional neuroleptics that primarily block postsynaptic receptors, Preclamol offers a more refined modulation of the dopaminergic system. This unique pharmacological profile makes it a valuable tool in schizophrenia research, aiming to alleviate psychotic symptoms with a potentially lower risk of extrapyramidal side effects.
In vitro	In vitro biochemical and electrophysiological assays demonstrate that Preclamol hydrochloride binds with high selectivity to dopamine autoreceptors. It inhibits the activity of tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, and significantly reduces the spontaneous firing rate of dopaminergic neurons. This mode of action establishes it as a standard reference compound for studying presynaptic regulatory mechanisms [1].
Synonyms	(-)-3-PPP hydrochloride

Chemical Properties

Molecular Weight	255.78
Formula	C₁₄H₂₂ClNO
Cas No.	88768-67-6
Smiles	C(CC)N1C[C@@H](CCC1)C2=CC(O)=CC=C2.Cl

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (156.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9096 mL	19.5480 mL	39.0961 mL	195.4805 mL
5 mM	0.7819 mL	3.9096 mL	7.8192 mL	39.0961 mL
10 mM	0.3910 mL	1.9548 mL	3.9096 mL	19.5480 mL
20 mM	0.1955 mL	0.9774 mL	1.9548 mL	9.7740 mL
50 mM	0.0782 mL	0.3910 mL	0.7819 mL	3.9096 mL
100 mM	0.0391 mL	0.1955 mL	0.3910 mL	1.9548 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc