Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12D, G12C, G12V, G12S, G12A, Q61H), while showing significantly reduced inhibition, with an IC50 >10 μM, for the KRAS G13D mutant [1].
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Description | Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12D, G12C, G12V, G12S, G12A, Q61H), while showing significantly reduced inhibition, with an IC50 >10 μM, for the KRAS G13D mutant [1]. |
Molecular Weight | 584.66 |
Formula | C34H34F2N4O3 |
CAS No. | 2882825-14-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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pan-KRAS-IN-2 2882825-14-9 GPCR/G Protein MAPK Ras inhibitor inhibit