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NP-BTA
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Catalog No. T87032Cas No. 544420-99-7
NP-BTA, an allosteric inhibitor of glutaminyl-tRNA synthetase (GlnRS), demonstrates antifungal activity against Candida albicans, with a MIC50 of 6.25 μM [1].
NP-BTA
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Catalog No. T87032Cas No. 544420-99-7
NP-BTA, an allosteric inhibitor of glutaminyl-tRNA synthetase (GlnRS), demonstrates antifungal activity against Candida albicans, with a MIC50 of 6.25 μM [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | NP-BTA, an allosteric inhibitor of glutaminyl-tRNA synthetase (GlnRS), demonstrates antifungal activity against Candida albicans, with a MIC50 of 6.25 μM [1]. |
| In vitro | NP-BTA (300 μM) inhibits GlnRS by binding with His6-Gln4 (K D of 180 nM), thereby preventing the aminoacylation of tRNA Gln, with an IC 50 of 106 nM [1]. |
| In vivo | NP-BTA (0.096–0.27 g 2% NP-BTA cream, applied twice daily for 7 days) helps protect immunosuppressed CD-1 mice from infection by T. mentagrophytes conidia [1]. Animal Model: Immunosuppressed CD-1 mice infected with T. mentagrophytes [1] Dosage: 0.096–0.27 g 2% NP-BTA cream Administration: Topical application, twice daily for 7 days Result: Reduced fungal burden. |
| Molecular Weight | 231.27 |
| Formula | C11H9N3OS |
| Cas No. | 544420-99-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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