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ML329
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Catalog No. T4028Cas No. 19992-50-8
ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.
ML329
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Purity: 98.96%
Catalog No. T4028Cas No. 19992-50-8
ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $48 | In Stock | In Stock | |
| 2 mg | $67 | In Stock | In Stock | |
| 5 mg | $117 | In Stock | In Stock | |
| 10 mg | $197 | In Stock | In Stock | |
| 25 mg | $447 | In Stock | In Stock | |
| 50 mg | $659 | In Stock | In Stock | |
| 100 mg | $939 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $121 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.96%
Appearance:Solid
Color:Orange
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity. |
| Targets&IC50 | MITF:1.2 μM. |
| In vitro | ML329 effectively reduces the expression of various micropthalmia-associated transcription factor (MITF) target genes and impedes the growth of several cell lines reliant on MITF for proliferation. This compound potentially interacts with MITF or its regulatory elements directly or indirectly. Given MITF's critical role in regulating the cell cycle and pigmentation, ML329's interference with MITF presents a promising approach to elucidate MITF's specific functions in melanoma and to assess the inhibition of MITF's activity as a viable melanoma treatment strategy. Notably, ML329 selectively targets MITF-dependent cells and primary melanocytes without affecting the viability of A375 cells. It also diminishes the expression of key MITF target genes involved in pigmentation and cell cycle regulation, such as CDK2. Thus, ML329 serves as an invaluable research tool to explore MITF's contribution to the development of melanocyte lineage and the progression of melanoma. |
| Molecular Weight | 328.34 |
| Formula | C16H12N2O4S |
| Cas No. | 19992-50-8 |
| Smiles | NS(=O)(=O)c1ccc(NC2=CC(=O)c3ccccc3C2=O)cc1 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (30.46 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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