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Moxilubant HCl

Name: Moxilubant HCl
Brand: TargetMol
SKU: T68108L
Price: 82 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T68108LCas No. 146957-32-6

Alias Moxilubant hcl(146978-48-5 Free base)

Moxilubant HCl is a small molecule leukotriene B4 receptor 1 (LTB4R) antagonist for the treatment of immune system disorders, skin and musculoskeletal disorders, and may be used in studies of psoriasis and rheumatoid arthritis.

Moxilubant HCl

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Purity: 99.94%

Catalog No. T68108LAlias Moxilubant hcl(146978-48-5 Free base)Cas No. 146957-32-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$82	In Stock	In Stock
5 mg	$181	In Stock	In Stock
10 mg	$267	In Stock	In Stock
25 mg	$413	In Stock	In Stock
50 mg	$592	In Stock	In Stock
100 mg	$819	In Stock	In Stock
200 mg	$1,090	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Moxilubant HCl is a small molecule leukotriene B4 receptor 1 (LTB4R) antagonist for the treatment of immune system disorders, skin and musculoskeletal disorders, and may be used in studies of psoriasis and rheumatoid arthritis.
In vitro	Moxilubant hcl inhibits LTB4 signaling with a potency of 2–4 nM.
In vivo	Moxilubant hcl (100 to 500 mg; oral; once or twice daily for 7 days) inhibition LTB4 pathway reached at least 75% (150 mg) and pathway inhibition reached 100% (300 mg).[1]
Synonyms	Moxilubant hcl(146978-48-5 Free base)

Chemical Properties

Molecular Weight	492.05
Formula	C₂₆H₃₈ClN₃O₄
Cas No.	146957-32-6
Smiles	Cl.O=C(C1=CC=C(OCCCCCOC2=CC=C(C=C2)C(=N)N)C(OC)=C1)N(C(C)C)C(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (101.62 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0323 mL	10.1616 mL	20.3231 mL	101.6157 mL
5 mM	0.4065 mL	2.0323 mL	4.0646 mL	20.3231 mL
10 mM	0.2032 mL	1.0162 mL	2.0323 mL	10.1616 mL
20 mM	0.1016 mL	0.5081 mL	1.0162 mL	5.0808 mL
50 mM	0.0406 mL	0.2032 mL	0.4065 mL	2.0323 mL
100 mM	0.0203 mL	0.1016 mL	0.2032 mL	1.0162 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc