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Moxilubant HCl

🥰Excellent
Catalog No. T68108LCas No. 146957-32-6
Alias Moxilubant hcl(146978-48-5 Free base)

Moxilubant HCl is a small molecule leukotriene B4 receptor 1 (LTB4R) antagonist for the treatment of immune system disorders, skin and musculoskeletal disorders, and may be used in studies of psoriasis and rheumatoid arthritis.

Moxilubant HCl

Moxilubant HCl

🥰Excellent
Purity: 99.19%
Catalog No. T68108LAlias Moxilubant hcl(146978-48-5 Free base)Cas No. 146957-32-6
Moxilubant HCl is a small molecule leukotriene B4 receptor 1 (LTB4R) antagonist for the treatment of immune system disorders, skin and musculoskeletal disorders, and may be used in studies of psoriasis and rheumatoid arthritis.
Pack SizePriceAvailabilityQuantity
1 mg$82In Stock
5 mg$181In Stock
10 mg$267In Stock
25 mg$413In Stock
50 mg$592In Stock
100 mg$819In Stock
200 mg$1,090In Stock
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Purity:99.19%
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Product Introduction

Bioactivity
Description
Moxilubant HCl is a small molecule leukotriene B4 receptor 1 (LTB4R) antagonist for the treatment of immune system disorders, skin and musculoskeletal disorders, and may be used in studies of psoriasis and rheumatoid arthritis.
In vitro
Moxilubant hcl inhibits LTB4 signaling with a potency of 2–4 nM.
In vivo
Moxilubant hcl (100 to 500 mg; oral; once or twice daily for 7 days) inhibition LTB4 pathway reached at least 75% (150 mg) and pathway inhibition reached 100% (300 mg).[1]
SynonymsMoxilubant hcl(146978-48-5 Free base)
Chemical Properties
Molecular Weight492.05
FormulaC26H38ClN3O4
Cas No.146957-32-6
SmilesCl.O=C(C1=CC=C(OCCCCCOC2=CC=C(C=C2)C(=N)N)C(OC)=C1)N(C(C)C)C(C)C
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (101.62 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0323 mL10.1616 mL20.3231 mL101.6157 mL
5 mM0.4065 mL2.0323 mL4.0646 mL20.3231 mL
10 mM0.2032 mL1.0162 mL2.0323 mL10.1616 mL
20 mM0.1016 mL0.5081 mL1.0162 mL5.0808 mL
50 mM0.0406 mL0.2032 mL0.4065 mL2.0323 mL
100 mM0.0203 mL0.1016 mL0.2032 mL1.0162 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

Moxilubant HClLTB4
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