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FGFR4-IN-5

Name: FGFR4-IN-5
Brand: TargetMol
SKU: T37425
Rating: 4.5 (1 reviews)

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Catalog No. T37425Cas No. 1628793-01-0

Alias FGFR4-IN-5

FGFR4-IN-5, a covalent FGFR4 inhibitor, demonstrates potency and selectivity with an IC50 value of 6.5 nM. Exhibiting significant in vivo anti-tumor activity, it is applicable for research in hepatocellular carcinoma [1].

FGFR4-IN-5

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Catalog No. T37425Alias FGFR4-IN-5Cas No. 1628793-01-0

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,670	6-8 weeks	6-8 weeks
50 mg	$2,180	6-8 weeks	6-8 weeks
100 mg	$2,800	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	FGFR4-IN-5, a covalent FGFR4 inhibitor, demonstrates potency and selectivity with an IC50 value of 6.5 nM. Exhibiting significant in vivo anti-tumor activity, it is applicable for research in hepatocellular carcinoma [1].
Targets&IC50	FGFR4:6.5 nM (IC50), FGFR2:505 nM (IC50)
In vivo	FGFR4-IN-5, administered via oral gavage at 10 mg/kg (single dose), shows high Cmax and low clearance, with Cmax values of 423 ng/ml in mice, 588 ng/ml in rats, and 2820 ng/ml in cynomolgus monkeys, and oral bioavailability of 20%, 12%, and 27%, respectively [1]. FGFR4-IN-5 (oral gavage; 100 mg/kg; twice daily; 28 days) demonstrates significant antitumor activity in an orthotopic Hep3B HTX model [1]. FGFR4-IN-5 (oral gavage; 10, 30, and 100 mg/kg; twice daily; 11 days) induces dose-dependent tumor growth inhibition, with regression at 30 and 100 mg/kg and %δT/δC values of 67% and 70%, respectively, while sorafenib (100 mg/kg; once daily) shows no in vivo benefit [1].
Synonyms	FGFR4-IN-5

Chemical Properties

Molecular Weight	520.37
Formula	C₂₃H₂₃Cl₂N₅O₅
Cas No.	1628793-01-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (192.17 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (6.34 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9217 mL	9.6085 mL	19.2171 mL	96.0855 mL
5 mM	0.3843 mL	1.9217 mL	3.8434 mL	19.2171 mL
10 mM	0.1922 mL	0.9609 mL	1.9217 mL	9.6085 mL
20 mM	0.0961 mL	0.4804 mL	0.9609 mL	4.8043 mL
50 mM	0.0384 mL	0.1922 mL	0.3843 mL	1.9217 mL
100 mM	0.0192 mL	0.0961 mL	0.1922 mL	0.9609 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc