Beta-Zearalanol

Name: Beta-Zearalanol
Brand: TargetMol
SKU: T14548
Rating: 4.5 (1 reviews)

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Catalog No. T14548Cas No. 42422-68-4

Beta-Zearalenol, a derivative of zearalenone (ZEA) capable of conjugating with glucuronic acid[2], is a mycotoxin produced by Fusarium spp. It induces apoptosis and oxidative stress in mammalian reproductive cells[1].

Beta-Zearalanol

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Catalog No. T14548Cas No. 42422-68-4

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Product Introduction

Bioactivity

Description

In vitro

βeta-Zearalenol (0-200 μM; 24 hours) inhibits BGC proliferation dose-dependently, with an IC50 of 25 μM[1]. βeta-Zearalenol (0-10 μM; 72 hours) exhibits the highest inhibition of the cytokines IL-8, IL-1β, and TNF-α compared to ZEA or α-Zearalenol[2]. βeta-Zearalenol (0-100 μM; 72 hours) is highly toxic to HepG2 cells with an IC50 of 15.2 μM, showing synergistic effects when combined with ZEN or α-ZOL, resulting in IC50 values of 19.8 μM and 16.8 μM, respectively[2].

Chemical Properties

Molecular Weight	322.4
Formula	C₁₈H₂₆O₅
Cas No.	42422-68-4
Smiles	OC1=C2C(=CC(O)=C1)CCCCC[C@H](O)CCC[C@H](C)OC2=O
Relative Density.	1.153g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc