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Rivenprost

Name: Rivenprost
Brand: TargetMol
SKU: T36080
Rating: 4.5 (1 reviews)

(Synonyms: ONO-AE1-734, ONO-4819, ONO4819, ONO 4819) Copy Product Info

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Synonyms: ONO-AE1-734, ONO-4819, ONO4819, ONO 4819

Catalog No. T36080 Copy Product Info

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Rivenprost is a selective agonist of the prostaglandin E receptor (EP4), exhibiting extremely high selectivity for the EP4 receptor with a Ki value of 0.7 nM. Rivenprost can be used in research on bone metabolism regulation, as well as anti-inflammatory and tissue protection studies.

Cas No. 256382-08-8

Pack Size	Price	USA Stock	Global Stock
100 μg (2.22 mM * 100 μL in Methyl acetate)	$142	35 days	35 days
500 μg (2.22 mM * 500 μL in Methyl acetate)	$539	35 days	35 days
1 mg (2.22 mM * 1 mL in Methyl acetate)	$987	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Liquid

Color:Transparent

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Product Introduction

Bioactivity

Description	Rivenprost is a selective agonist of the prostaglandin E receptor (EP4), exhibiting extremely high selectivity for the EP4 receptor with a Ki value of 0.7 nM. Rivenprost can be used in research on bone metabolism regulation, as well as anti-inflammatory and tissue protection studies.
Targets & IC50	EP4:0.7 nM (Ki)
In vitro	Method: Rivenprost (1 nM, 10 nM, 100 nM, 1 μM) was added to C3H10T1/2 cells, which were incubated for 7 days, followed by ALPase activity assays. Results: Rivenprost induced ALPase activity in a concentration-dependent manner and stimulated osteoblast differentiation. [2]
In vivo	Methods: To investigate the intraocular pressure-lowering effects of Rivenprost, 0.005% Rivenprost (50 μg/mL) was instilled into both eyes of DBA/2J mice (spontaneous pigmentary glaucoma) at a dose of approximately 5 μL per eye, once daily for 14 days. Results: Rivenprost effectively reduced the elevated intraocular pressure caused by glaucoma. [1] Methods: SD rats were administered Rivenprost (10 μg/kg) via subcutaneous injection twice daily for 5 weeks. Results: Rivenprost significantly increased bone volume, trabecular bone count, mineralization rate, and bone formation rate. [2] Methods: Wistar rats received a single intraperitoneal injection of ONO-4819 (0.2 mg/kg), GalN (1 g/kg), or LPS (100 mg/kg); ONO-4819 was administered concurrently with GalN/LPS. Results: Rivenprost exerts a hepatoprotective effect against GalN/LPS-induced liver injury in Wistar rats via inflammatory cytokines such as TNF-α. [3]
Synonyms	ONO-AE1-734, ONO-4819, ONO4819, ONO 4819

Chemical Properties

Molecular Weight	450.59
Formula	C₂₄H₃₄O₆S
Cas No.	256382-08-8
Smiles	C(=C/[C@H](CC1=CC(COC)=CC=C1)O)\[C@@H]2[C@@H](CCSCCCC(OC)=O)C(=O)C[C@H]2O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMF: 15 mg/mL (33.29 mM), Sonication is recommended.

Ethanol: 15 mg/mL (33.29 mM), Sonication is recommended.

DMSO: 10 mg/mL (22.19 mM), Sonication is recommended.

Solution Preparation Table

DMSO/DMF/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.2193 mL	11.0966 mL	22.1931 mL	110.9656 mL
5 mM	0.4439 mL	2.2193 mL	4.4386 mL	22.1931 mL
10 mM	0.2219 mL	1.1097 mL	2.2193 mL	11.0966 mL
20 mM	0.1110 mL	0.5548 mL	1.1097 mL	5.5483 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.