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Rivenprost

Name: Rivenprost
Brand: TargetMol
SKU: T36080
Rating: 4.5 (1 reviews)

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Catalog No. T36080Cas No. 256382-08-8

Alias ONO-4819

Prostaglandin E2 activates four distinct G protein-coupled receptors, EP1-4. Rivenprost is a potent and selective agonist for the EP4 receptor (Ki = 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively). It has been used to promote EP4-mediated bone formation, prevent bone loss related to osteoporosis, drive osteoblast differentiation, and stabilize bone implants.[1][2][3][4][5] Rivenprost has also been used to support wound healing.[6]

Rivenprost

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Catalog No. T36080Alias ONO-4819Cas No. 256382-08-8

Pack Size	Price	USA Warehouse	Global Warehouse
100 μg	$142	35 days	35 days
500 μg	$539	35 days	35 days
1 mg	$987	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Prostaglandin E2 activates four distinct G protein-coupled receptors, EP1-4. Rivenprost is a potent and selective agonist for the EP4 receptor (Ki = 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively). It has been used to promote EP4-mediated bone formation, prevent bone loss related to osteoporosis, drive osteoblast differentiation, and stabilize bone implants.[1][2][3][4][5] Rivenprost has also been used to support wound healing.[6]
Targets&IC50	EP4:0.7 nM (Ki)
Synonyms	ONO-4819

Chemical Properties

Molecular Weight	450.59
Formula	C₂₄H₃₄O₆S
Cas No.	256382-08-8
Smiles	C(=C/[C@H](CC1=CC(COC)=CC=C1)O)\[C@@H]2[C@@H](CCSCCCC(OC)=O)C(=O)C[C@H]2O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMF: 30 mg/mL (66.58 mM), Sonication is recommended.

Ethanol: 30 mg/mL (66.58 mM), Sonication is recommended.

DMSO: 20 mg/mL (44.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO/DMF/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.2193 mL	11.0966 mL	22.1931 mL	110.9656 mL
5 mM	0.4439 mL	2.2193 mL	4.4386 mL	22.1931 mL
10 mM	0.2219 mL	1.1097 mL	2.2193 mL	11.0966 mL
20 mM	0.1110 mL	0.5548 mL	1.1097 mL	5.5483 mL

DMF/Ethanol

	1mg	5mg	10mg	50mg
50 mM	0.0444 mL	0.2219 mL	0.4439 mL	2.2193 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc