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Rivenprost

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Catalog No. T36080Cas No. 256382-08-8
Alias ONO-4819

Prostaglandin E2 activates four distinct G protein-coupled receptors, EP1-4. Rivenprost is a potent and selective agonist for the EP4 receptor (Ki = 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively). It has been used to promote EP4-mediated bone formation, prevent bone loss related to osteoporosis, drive osteoblast differentiation, and stabilize bone implants.[1][2][3][4][5] Rivenprost has also been used to support wound healing.[6]

Rivenprost

Rivenprost

😃Good
Catalog No. T36080Alias ONO-4819Cas No. 256382-08-8
Prostaglandin E2 activates four distinct G protein-coupled receptors, EP1-4. Rivenprost is a potent and selective agonist for the EP4 receptor (Ki = 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively). It has been used to promote EP4-mediated bone formation, prevent bone loss related to osteoporosis, drive osteoblast differentiation, and stabilize bone implants.[1][2][3][4][5] Rivenprost has also been used to support wound healing.[6]
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
100 μg$14235 days35 days
500 μg$53935 days35 days
1 mg$98735 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Prostaglandin E2 activates four distinct G protein-coupled receptors, EP1-4. Rivenprost is a potent and selective agonist for the EP4 receptor (Ki = 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively). It has been used to promote EP4-mediated bone formation, prevent bone loss related to osteoporosis, drive osteoblast differentiation, and stabilize bone implants.[1][2][3][4][5] Rivenprost has also been used to support wound healing.[6]
Targets&IC50
EP4:0.7 nM (Ki)
SynonymsONO-4819
Chemical Properties
Molecular Weight450.59
FormulaC24H34O6S
Cas No.256382-08-8
SmilesC(=C/[C@H](CC1=CC(COC)=CC=C1)O)\[C@@H]2[C@@H](CCSCCCC(OC)=O)C(=O)C[C@H]2O
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMF: 30 mg/mL (66.58 mM), Sonication is recommended.
Ethanol: 30 mg/mL (66.58 mM), Sonication is recommended.
DMSO: 20 mg/mL (44.39 mM), Sonication is recommended.
Solution Preparation Table
DMSO/DMF/Ethanol
1mg5mg10mg50mg
1 mM2.2193 mL11.0966 mL22.1931 mL110.9656 mL
5 mM0.4439 mL2.2193 mL4.4386 mL22.1931 mL
10 mM0.2219 mL1.1097 mL2.2193 mL11.0966 mL
20 mM0.1110 mL0.5548 mL1.1097 mL5.5483 mL
DMF/Ethanol
1mg5mg10mg50mg
50 mM0.0444 mL0.2219 mL0.4439 mL2.2193 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

RivenprostONO4819ONO 4819
Related Tags: buy Rivenprost | purchase Rivenprost | Rivenprost cost | order Rivenprost | Rivenprost chemical structure | Rivenprost formula | Rivenprost molecular weight
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