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PROTAC AR Degrader-5
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Catalog No. T87255Cas No. 2703021-51-4
PROTAC AR Degrader-5 (compound A46) is a powerful AR PROTAC Degrader exhibiting an IC 50 of 49 nM. It not only inhibits sebaceous plaque but also promotes hair regeneration [1].
PROTAC AR Degrader-5
😃Good
Catalog No. T87255Cas No. 2703021-51-4
PROTAC AR Degrader-5 (compound A46) is a powerful AR PROTAC Degrader exhibiting an IC 50 of 49 nM. It not only inhibits sebaceous plaque but also promotes hair regeneration [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PROTAC AR Degrader-5 (compound A46) is a powerful AR PROTAC Degrader exhibiting an IC 50 of 49 nM. It not only inhibits sebaceous plaque but also promotes hair regeneration [1]. |
| In vivo | The chemical compound PROTAC AR Degrader-5 (compound A46) exhibits significant bioactivity in both Syrian hamsters and C57BL/6N mice. In a Syrian hamster model, daily dermal applications of 100, 200, 400, and 800 µg combined with 12 µg TP for 21 days resulted in sebaceous gland suppression with inhibition rates of 19.24%, 35.20%, 49.54%, and 51.61% respectively. In the C57BL/6N mouse model, dermal doses of 5, 10, and 30 mg/ml with DHT 30 mpk applied twice daily for 17 days successfully induced hair regrowth. The test subjects were female Syrian hamsters aged 7-8 weeks and weighing 90-110 grams. |
| Molecular Weight | 1043.16 |
| Formula | C52H54F4N8O7S2 |
| Cas No. | 2703021-51-4 |
| Smiles | S=C1N(C(=O)C(C)(C)N1C=2C=CC(=NC2)C3=CC=C(OCCCCOCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)C(C)(C)C)=O)C=C3)C7=C(F)C(C(F)(F)F)=C(C#N)C=C7 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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