Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DOTA-LM3 TFA is a somatostatin receptor (SSTR) antagonist with the molecular structure p-Cl-Phe-cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH2. It is effectively used in tracing tumors in vivo through isotopic labeling, examples being 177Lu-DOTA-LM3 TFA and 68Ga-DOTA-LM3 TFA. The 68Ga-labeled compound demonstrates favorable biodistribution, high tumor uptake, good tumor retention, and minimal safety concerns. Meanwhile, the 177Lu-labeled variant is utilized in research targeting DOTATOC-negative liver metastases such as pancreatic NET and extensive tumor thrombosis [1] [2].
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Description | DOTA-LM3 TFA is a somatostatin receptor (SSTR) antagonist with the molecular structure p-Cl-Phe-cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH2. It is effectively used in tracing tumors in vivo through isotopic labeling, examples being 177Lu-DOTA-LM3 TFA and 68Ga-DOTA-LM3 TFA. The 68Ga-labeled compound demonstrates favorable biodistribution, high tumor uptake, good tumor retention, and minimal safety concerns. Meanwhile, the 177Lu-labeled variant is utilized in research targeting DOTATOC-negative liver metastases such as pancreatic NET and extensive tumor thrombosis [1] [2]. |
In vitro | The compound 177Lu-DOTA-LM3 TFA is tolerable and primarily accumulates in the systemic circulation, kidneys, spleen, and metastatic lesions, resulting in higher average absorbed doses to these organs and tumors [2]. |
Molecular Weight | 1664.18 |
Formula | C71H94ClF3N16O21S2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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DOTA-LM3 TFA inhibitor inhibit