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Dafsolimab

Name: Dafsolimab
Brand: TargetMol
SKU: T80597
Rating: 4.5 (1 reviews)

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Catalog No. T80597Cas No. 2367001-71-4

Alias SPV-T3a

Dafsolimab (SPV-T3a), an IgG2a murine monoclonal antibody (anti-CD3), induces cell death by modulating and activating the CD3/T cell receptor complex and is utilized in research pertaining to graft-versus-host disease (GVHD) [1].

Dafsolimab

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Catalog No. T80597Alias SPV-T3aCas No. 2367001-71-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	Inquiry	Backorder	Backorder
5 mg	Inquiry	Backorder	Backorder

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Instruction Manual of Inhibitory Antibody

Product Introduction

Bioactivity

Description	Dafsolimab (SPV-T3a), an IgG2a murine monoclonal antibody (anti-CD3), induces cell death by modulating and activating the CD3/T cell receptor complex and is utilized in research pertaining to graft-versus-host disease (GVHD) [1].
In vitro	In the absence of PHA activation, SPV-T3a-dgA (1.8 μg/mL) resulted in a 2.0-2.7 fold reduction in viable cell count. After 48 hours of PHA activation, the cytotoxicity of SPV-T3a-DGA increased approximately threefold.
Synonyms	SPV-T3a
Reactivity	Human
Application	ELISA FACS Functional assay
Antibody Type	Monoclonal
Host Species	＜ 1.0 EU/mg

Related Conjugates and Formulations

Conjucates

Unconjugated

Chemical Properties

Cas No.

2367001-71-4

Storage & Solubility Information

Storage

-20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc