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Monomethyl lithospermate

Name: Monomethyl lithospermate
Brand: TargetMol
SKU: TN3323
Rating: 4.5 (1 reviews)

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Catalog No. TN3323Cas No. 933054-33-2

Alias Lithospermic acid monomethyl ester

Monomethyl lithospermate (Lithospermic acid monomethyl ester) has potential antiviral activity, alleviating ischemic stroke injury in vivo in middle cerebral artery occlusion mice by activating PI5K/Akt signaling and protecting oxygen-glucose deprivation/reoxygenation-induced SHSY-3Y cells in vitro. Monomethyl lithospermate could improve the viability of SHSY-5Y cells, inhibit mitochondrial membrane potential (MMOP) collapse, and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of middle artery occlusion (MCAO) rats and improved nerve damage in ischemic stroke (IS) rats.

Monomethyl lithospermate

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Catalog No. TN3323Alias Lithospermic acid monomethyl esterCas No. 933054-33-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$358	Inquiry	Inquiry
5 mg	$879	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description	Monomethyl lithospermate (Lithospermic acid monomethyl ester) has potential antiviral activity, alleviating ischemic stroke injury in vivo in middle cerebral artery occlusion mice by activating PI5K/Akt signaling and protecting oxygen-glucose deprivation/reoxygenation-induced SHSY-3Y cells in vitro. Monomethyl lithospermate could improve the viability of SHSY-5Y cells, inhibit mitochondrial membrane potential (MMOP) collapse, and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of middle artery occlusion (MCAO) rats and improved nerve damage in ischemic stroke (IS) rats.
In vitro	Monomethyl lithospermate (5, 10 and 20 μM; 12 h) increases cell viability of SHSY-5Y cells treated with oxygen-glucose deprivation and reperfusion (OGD/R).[1] Monomethyl lithospermate (20 μM; 12 h) reduces cell damage, mitochondrial membrane potential loss, and apoptosis in SHSY-5Y cells after hypoxia, glucose deprivation/reoxygenation.[1] Monomethyl lithospermate (5, 10 and 20 μM; 12 h) reduces ROS and intracellular oxidative stress in SHSY-5Y cells.[1] Monomethyl lithospermate (20 μM; 12 h) activates PI3K/AKT in SHSY-5Y cells.[1]
In vivo	Monomethyl lithospermate (72.4 μM/kg; oral; once daily for 14 days) improves neurological function, reduces cerebral infarct size, oxidative stress levels, and neuronal apoptosis in rats with ischemia-reperfusion (IR) 24 h after middle artery occlusion (MCAO) by activating PI3K/AKT.[1]
Synonyms	Lithospermic acid monomethyl ester

Chemical Properties

Molecular Weight	552.48
Formula	C₂₈H₂₄O₁₂
Cas No.	933054-33-2
Smiles	C(OC)(=O)[C@H]1C=2C(O[C@@H]1C3=CC(O)=C(O)C=C3)=C(O)C=CC2/C=C/C(O[C@H](CC4=CC(O)=C(O)C=C4)C(O)=O)=O
Relative Density.	1.564 g/cm3 (Predicted)

Storage & Solubility Information

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store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc